Berlin-Brandenburg Pregnancy Cohort

This study will investigate the interplay of different immune cells and placental cells as well as their potential for the development of pregnancy complications. In particular, the translation of the uteroplacental syndrome into a maternal syndrome, considered in the multifactorial pregnancy disorder preeclampsia, will be investigated. Immune cell subtypes are causally involved in the formation and translation of preeclampsia by inducing an endothelial dysfunction which leads to cardiovascular damage.

Recruiting

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Key information

Conditions

Preeclampsia Diabetes Mellitus Diabetes Mellitus in Pregnancy Diabetes, Gestational Endocrine System Diseases Female Urogenital Diseases and Pregnancy Complications Glucose Metabolism Disorders Hypertension, Pregnancy-Induced Metabolic Diseases Nutritional and Metabolic Diseases Pre-Eclampsia Pregnancy Complications Urogenital Diseases

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Experimental and Clinical Research Center (ECRC)

Berlin, 13125, Germany

Location status: Recruiting

Location contact

Florian Herse, PhD

CONTACT

[email protected]

+49 30 450 540 434

Florian Herse, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy pregnant women after giving informed consent
pregnant with diagnosis of preeclampsia, gestational hypertension or gestational diabetes

Exclusion criteria

infections
alcohol and drug abuse
manifest and chronic diseases

Treatment and study plan

Primary outcomes

T cell population content at the time of preeclampsia diagnosis compared to controls and verified by flow cytometry

Time frame: at the time of preeclampsia diagnosis compared to controls at the same time point in pregnancy

Study contacts

Contact information is provided by the study sponsor or research team.

Florian Herse, PhD

CONTACT

[email protected]

+49 30 450 540 434

Sponsors and collaborators

Lead sponsor

Charite University, Berlin, Germany

Other

Registry information

Official study title

Characterization of Immune Cell-trophoblast-interaction in Pregnancy Disorders

Acronym: BBPC

Important dates

Study start: 2017
Primary completion: 2027
Study completion: 2027
First posted: Oct 18, 2017
Registry last updated: Aug 14, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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