Berberine and Polycystic Ovary Syndrome

Homeostasis Model Assessment (pt), for evaluate insulin resistance if > 2.4

C-Reactive Protein (mg/dl)

Tumor Necrosis Factor alpha (pg/ml)

Total Cholesterol (mg/dl), High Density Lipoprotein Cholesterol (mg/dl), Low Density Lipoprotein Cholesterol (mg/dl), Very Low Density Lipoprotein (mg/dl),Triglycerides (mg/dl)

Glycemia (mg/dl)

Insulin (mcU/ml)

Sex Hormone Binding Globulin (nmol/l)

Testosterone (ng/ml)

Free Androgen Index (ratio)

Aspartate aminotransferase (IU/l), alanine aminotransferase (IU/l)

Total bilirubin (mg/dl)

Gamma Glutamyl Transferase (U/I), Creatine Phosphokinase (U/I)

waist circumference (cm), hip circumference (cm)

Weight (kg)

Body Mass Index (Kg/m2)

Fat mass (g), lean mass (g), visceral adipose tissue (g)

Global Acne Grading System (scale): each type of acne lesion is given a value depending on severity: no lesions = 0, comedones = 1, papules = 2, pustules = 3, and nodules = 4. Each of the location was graded separately on 0-4 scale, with the most severe lesion within that location determining the local score. The severity was then graded according to the global score which is the summation of all local scores. A score of 1-6 was considered mild; 7-18, moderate; 19- 26, severe; and 27-32, very severe. The maximum score was 32

Cardiff Acne Disability Index (scale): the Cardiff Acne Disability Index consists of five questions with a Likert scale, four response categories (0-3). The five questions relate to feeling of aggression, frustration, interference with social life, avoidance of public changing facilities and appearance of the skin-all over the last month-and an indication of how bad the acne was now. The CADI score was calculated by summing the score of each question resulting in a possible maximum of 15 and minimum of 0. CADI scores were graded as low (0-4), medium (5-9), and high (10-15)