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NCT Number: NCT02654301

Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia

The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).

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Key information

Conditions

Postprandial Hyperglycemia Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Hyperglycemia Metabolic Diseases Nutritional and Metabolic Diseases Prediabetic State

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

In this double-blind crossover designed study, Participants were randomly assigned to consume a sucrose drink (Control, sucrose 50g + deionized water 100g) or a sucrose drink additionally containing 5 g (Test 1, sucrose : xylose = 10:1), 3.33 g (Test 2, sucrose : xylose = 15:1) or 2.5 g (Test 3, sucrose : xylose = 20:1) of D-xylose with a week interval.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy subject or Impaired fasting glucose (fasting serum glucose between 100 and 125 mg/dL)

Exclusion criteria

  • history of taking an insulin-injection or oral hypoglycemic agents
  • evidence of alcohol abuse or alcoholism
  • pregnancy or breast feeding
  • chronic gastrointestinal disorder
  • seriously abnormal liver or renal function
  • an occupation at risk of death when hypoglycemia occurs

Treatment and study plan

Test 1

Dietary Supplement

sucrose : xylose = 10:1, sucrose 50 g + xylose 5 g + deionized water 95 g

Test 2

Dietary Supplement

sucrose : xylose = 15:1, sucrose 50 g + xylose 3.33 g + deionized water 96.67 g

Test 3

Dietary Supplement

sucrose : xylose = 20:1, sucrose 50 g + xylose 2.5 g + deionized water 97.5 g

Control

Dietary Supplement

sucrose 50 g + deionized water 100 g

Primary outcomes

  1. Change of serum glucose levels

    Time frame: a week interval

Secondary outcomes

  1. Change of serum insulin levels

    Time frame: a week interval

  2. Change of serum C-peptide levels

    Time frame: a week interval

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Official study title

Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia in Subjects With Normal Glucose Level and Impaired Fasting Glucose

Important dates

Study start
2014
Primary completion
2014
Study completion
2015
First posted
Jan 13, 2016
Registry last updated
Jan 13, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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