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Completed

NCT Number: NCT03518567

Behavioral Economic Analysis of Demand for Marijuana

This laboratory study will employ a multi-session experimental design to examine the behavioral economic demand for marijuana, by studying effect of marijuana administration (High THC) on demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly.

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Key information

Conditions

Marijuana Smoking Behavior Marijuana Use Smoking Smoking, Non-Tobacco Products

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Brown University

Providence, Rhode Island, 02903, United States

About this study

This laboratory study will employ a multi-session experimental design to examine craving for marijuana, the effect of marijuana administration (High THC) on behavioral economic demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly. The relationship between hypothetical and actual demand for marijuana will be examined. We will also investigate relationship between demand for marijuana and indices of marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly to obtain a final sample of 85 with complete data (15% of attrition). Participants will be tested at a baseline session and during two experimental sessions (an ad libitum marijuana smoking session and a marijuana smoking topography session). This study will confirm the utility of the hypothetical marijuana purchase task as a reliable and valid tool for assessing behavioral economic marijuana demand.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • marijuana use at least 8 times in the past month on average and at least monthly for the past 6 months
  • English-speaking
  • negative urine toxicology screen for drugs other than marijuana
  • non-treatment seeking
  • purchase of marijuana at least twice in the past 6 months to confirm familiarity with the construct to be measured

Exclusion criteria

  • positive pregnancy test
  • nursing
  • inability to use contraception during the study
  • poor physical health
  • positive breath alcohol concentration
  • diagnosis of a current affective disorder, psychosis, and panic disorder
  • self-report of past serious adverse reaction to marijuana
  • current psychotropic drug use
  • smoking more than 20 tobacco cigarettes per day
  • inability to abstain from marijuana for 15 hours
  • body mass index outside 18.5-30 kg/m2 range

Treatment and study plan

Smoked marijuana cigarettes: High THC dose (6% THC)

Drug

Smoked marijuana cigarettes (High THC dose [6% THC])

Primary outcomes

  1. Validity of the Marijuana Purchase Task (MPT)

    Time frame: Duration of the experimental session (i.e., 60 minutes)

    The Marijuana Purchase Task will be used to collect data on marijuana demand. Participants indicate how much marijuana they would purchase at varying levels of price (e.g., free - $60). Indices of marijuana demand are derived from the task and used to determine the relative value of marijuana for each participant. Hits purchased on the MPT will correspond with actual number of hits purchased and smoked in the laboratory. Primary outcome is percentage of participants who purchased and smoked exactly what they said they would.

Secondary outcomes

  1. Change in Marijuana Craving Questionnaire (MCQ)

    Time frame: The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hours

    Subjective marijuana craving was assessed via a 10-item Marijuana Craving Questionnaire. Participants were asked to respond to items according to how they were thinking or feeling "right now," and MCQ items were rated on a 1 = "strongly disagree" to 7 = "strongly agree" scale, with higher scores indicating greater subjective marijuana craving, and summed to yield a total craving score. Total craving score was used in analyses.

  2. Marijuana Smoking Topography

    Time frame: Marijuana smoking topography indices will be collected during the 1-hour ad libitum marijuana smoking topography experimental session.

    Indices of Marijuana Smoking Topography will be obtained during the experimental session. Participants will smoke marijuana through a smoking topography device. The outcome measure is number of puffs.

Sponsors and collaborators

Lead sponsor

Brown University

Other

Registry information

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
May 8, 2018
Registry last updated
Feb 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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