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Completed

NCT Number: NCT05460351

Beetroot Juice Resistance Training Older Adults

The present study compared the effects of a nitrate containing beetroot juice supplement (BRJ+Nitrate) vs. a placebo (Control) on total and regional fat free mass, quadriceps muscle strength, lower body mobility, and VO2peak in healthy, older adults undergoing a 10-week long progressive resistance training program with protein supplementation.

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Old Age; Atrophy Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Able to provide own transportation to study testing visits and intervention
  • Able to read and write in English
  • Nondiabetic, i.e. fasting glucose < 126 mg/dl
  • Sedentary (less than 60 minutes of moderate intensity structured physical activity each week and occurs in no more than 10 minute blocks and not participating in a resistance exercise training program)
  • Willingness to provide informed consent and participate in intervention. Participants with diagnosed depression were permitted to participate provided that they have been medically stable without medication change for at least 3 months.

Exclusion criteria

  • Smoking or use of chewing tobacco
  • Involved in another intervention research study
  • Diabetic (type 1 or 2)
  • Atrophic gastritis
  • Hypo- or hyperthyroidism
  • Gout or history of kidney stones
  • History of hypotension
  • Premenopausal (women)
  • Aversion to study-related testing procedures
  • Allergy/sensitivity/aversion to beetroot beverages or protein supplement
  • Medical conditions with contraindications for engaging in resistance training program or taking the protein supplement
  • Systemic, uncontrolled diseases (diabetes, recent (last 6 months) or current treatment of cancer, thyroid disorders, cardiovascular disease, COPD, or inflammatory bowel diseases)
  • Use of any of the following medications: phosphodiesterase type 5 inhibitors, nitroglycerin or nitrate preparations, proton pump inhibitors, or medications for hypothyroidism
  • Potential inability to complete the tasks required for the protocol as well as conditions that may interfere with interpretation of results including: inability to ambulate, severe congestive heart failure or severe cardiovascular disease, neoplasm for practical and neurophysiologic reasons
  • Individuals with contraindications for performing a graded exercise test or have medical contraindications for participating in a scheduled exercise training program
  • Individuals more than 300 pounds or less than 125 pounds due to DEXA weight limits and possibility of exceeding recommended daily nitrate dose of 7 mg/kg body weight, respectively.

Treatment and study plan

BRJ+Nitrate

Dietary Supplement

Participants in this group drank a 70 mL bottle of Beet It Sport drink with nitrate plus 15 grams of whey protein 3 days a week following a resistance exercise training program

Control

Dietary Supplement

Participants in this group drank a 70 mL bottle of Beet It Sport drink without nitrate plus 15 grams of whey protein 3 days a week following a resistance exercise training program

Primary outcomes

  1. Whole body fat free mass

    Time frame: Collected at baseline

    Mass of fat free tissue

  2. Whole body fat mass

    Time frame: Collected at baseline

    Mass of fat tissue

  3. Thigh muscle

    Time frame: Collected at baseline

    Volume of thigh muscle

  4. Thigh intermuscular fat

    Time frame: Collected at baseline

    Volume of fat in the thigh muscle

  5. Thigh subcutaneous fat

    Time frame: Collected at baseline

    Volume of subcutaneous fat in the thigh

  6. Visceral fat

    Time frame: Collected at baseline

    Volume of visceral fat

  7. Muscle strength

    Time frame: Collected at baseline

    Strength of quadriceps muscle at a speed of 60 degrees per second

  8. 400 meter walk

    Time frame: Collected at baseline

    Time to walk 400 meters

  9. Stair climb time

    Time frame: Collected at baseline

    Time to ascend and descend 12 stairs

  10. Peak oxygen consumption

    Time frame: Collected at baseline

    Peak oxygen consumed at maximal exercise during graded exercise testing

  11. Whole body fat free mass

    Time frame: Collected at 10-weeks

    mass of fat free tissue

  12. Whole body fat mass

    Time frame: Collected at 10-weeks

    Mass of fat tissue

  13. Thigh muscle

    Time frame: Collected at 10-weeks

    Volume of thigh muscle

  14. Thigh intermuscular fat

    Time frame: Collected at 10-weeks

    Volume of fat in the thigh muscle

  15. Thigh subcutaneous fat

    Time frame: Collected at 10-weeks

    Volume of subcutaneous fat in the thigh

  16. Visceral fat

    Time frame: Collected at 10-weeks

    Volume of visceral fat

  17. Muscle strength

    Time frame: Collected at 10-weeks

    Strength of quadriceps muscle at a speed of 60 degrees per second

  18. 400 meter walk

    Time frame: Collected at 10-weeks

    Time to walk 400 meters

  19. Stair climb time

    Time frame: Collected at 10-weeks

    Time to ascend and descend 12 stairs

Sponsors and collaborators

Lead sponsor

Wake Forest University

Other

Registry information

Official study title

Effect of Beetroot Juice on Body Composition, Physical Function, Muscle Strength, and Peak Oxygen Consumption in Resistance Trained Older Adults Consuming a Protein Supplement

Important dates

Study start
2014
Primary completion
2014
Study completion
2015
First posted
Jul 15, 2022
Registry last updated
Jul 15, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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