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Completed

NCT Number: NCT03020862

Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients

The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) after supplementing with higher doses of dietary NO3-, compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

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Key information

Conditions

Chronic Obstructive Pulmonary Disease Moderate Behavior Motor Activity

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sport Science, Department of Public Health, Aarhus University

Aarhus, 8000, Denmark

About this study

The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) using the 6-minute walk test (6MWT) after supplementing with higher doses of dietary NO3- compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Moderate-severe Chronics Obstructive Pulmonary Disease (COPD) (FEV1 <80% of predicted).

Exclusion criteria

  • Smoking,
  • failure to complete physical testing,
  • on-going participation in rehabilitation programs,
  • pacemaker or use of nicotine products,
  • oxygen mask,
  • beta blockers,
  • antibacterial mouthwash,
  • chewing gum or stomach-neutralizing medicine during the intervention.

Treatment and study plan

Dietary beetroot juice

Dietary Supplement

Consumed as concentrated beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days.

Primary outcomes

  1. Physical performance on 6-min walk test (6MWT)

    Time frame: 6 minutes

Secondary outcomes

  1. Blood Pressure

    Time frame: At baseline and 150 minutes after consumption of beverages

  2. Plasma Nitrite concentration

    Time frame: Baseline, 150 and 210 minutes after consumption of beverages

  3. Oxygen consumption during submaximal cycling

    Time frame: Two trials of 6 minutes duration (10 min break between trials)

  4. Physical activity level

    Time frame: Six days

    Measured all intervention days except on the day of testing

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Acronym: COPD

Important dates

Study start
2013
Primary completion
2014
Study completion
2015
First posted
Jan 13, 2017
Registry last updated
Jan 16, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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