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Completed

NCT Number: NCT01706718

Beetroot Enriched Bread, Blood Pressure and Vascular Function

Dietary nitrate is known to lower blood pressure. Beetroot is a rich source of nitrate and could therefore be an important dietary component in the management of hypertension and cardiovascular disease, however consumption is relatively low. We evaluated the effects of beetroot enriched bread ingestion on acute microvascular reactivity, arterial stiffness and blood pressure response in healthy men.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

18 year–64 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Reading

Reading, Berkshire, RG6 6AP, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • A signed consent form
  • Age 18-64 years
  • Body mass index - 18.5-30 kg/m2
  • Non-smoking, healthy individuals
  • Normal blood pressure at screening (< 150/90)

Exclusion criteria

  • Subjects with anaemia
  • Sufferers of chronic illnesses
  • Individuals with food allergies
  • People with diabetes
  • People with coeliac disease
  • Women
  • Vegetarians

Treatment and study plan

Bread

Dietary Supplement

Primary outcomes

  1. Vascular reactivity

    Time frame: Change from baseline at 2, 4 and 6 hours after bread consumption

    Forearm blood flow by Laser Doppler Imaging with iontophoresis

Secondary outcomes

  1. Arterial stiffness

    Time frame: Change from baseline at 2, 4 and 6 hours after bread consumption

    Pulse wave analysis (PWA) and velocity (PWV)

  2. Blood pressure

    Time frame: Change from baseline at 30 minute intervals for 7 hours

    By ambulatory blood pressure monitor

  3. Plasma nitrate

    Time frame: Every 30 minutes for 7 hours

  4. Plasma nitrite

    Time frame: Every 30 minutes for 7 hours

Sponsors and collaborators

Lead sponsor

University of Reading

Other

Registry information

Official study title

The Effects of Beetroot Enriched Bread on Postprandial Vascular Function, Arterial Stiffness and Blood Pressure in Healthy Men

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Oct 15, 2012
Registry last updated
Oct 15, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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