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Completed

NCT Number: NCT02521025

Bedrest, Feeding Pattern, and Insulin Sensitivity

In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.

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Key information

Conditions

Atrophy, Disuse Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Muscular Diseases Muscular Disorders, Atrophic Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases Nutritional and Metabolic Diseases

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University Medical Center+

Maastricht, Limburg, 6229ER, Netherlands

About this study

In the present study, the investigators will assess the impact of two different feeding patterns on insulin sensitivity and muscle mass following bedrest. Healthy, young males will be fed in a continuous (no breaks in food supply) or intermittent (in boluses throughout the day) manner.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI between 18.5 and 35
  • Recreationally active

Exclusion criteria

  • Type 2 diabetes
  • Performing progressive resistance training in 6 months prior to study
  • Back/knee/leg problems
  • Hypertension
  • Use of certain anticoagulants
  • All co morbidities interacting with mobility and muscle metabolism of the lower limbs
  • Blood donation in past 3 months

Treatment and study plan

Intermittent feeding pattern

Other

Intermittent feeding

Continuous feeding pattern

Other

Continuous feeding

Primary outcomes

  1. Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp)

    Time frame: 7 days bedrest

Secondary outcomes

  1. Change in muscle mass (measured as upper leg muscle cross-sectional area with CT scan)

    Time frame: 7 days bedrest

    Via single-slice CT scan

  2. Change in lean tissue (measured via DEXA scan)

    Time frame: 7 days bedrest

    Via DEXA

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Official study title

The Impact of Continuous Versus Intermittent Feeding on Changes in Insulin Sensitivity During Bed-rest

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Aug 13, 2015
Registry last updated
Jul 27, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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