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Completed

NCT Number: NCT02109380

Bed-rest, Muscle Mass and Insulin Sensitivity

In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.

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Key information

Conditions

Disuse Atrophy Muscular Diseases Muscular Disorders, Atrophic Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University Medical Centre

Maastricht, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • Aged from 18-35 years
  • 18.5 < BMI < 30 kg/m2

Exclusion criteria

  • Smoking
  • Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
  • Hypertension (according to WHO criteria) and/or cardiovascular disease
  • Any back/leg/knee/neck/postural complaints
  • Use of any prescribed medication
  • Type 2 diabetes mellitus
  • Any family history of thrombosis
  • All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
  • Myocardial infarction within the last 3 years
  • Use of anti-coagulants

Treatment and study plan

Bed rest

Behavioral

Primary outcomes

  1. Change in quadriceps muscle cross-sectional area

    Time frame: One day before and directly after cessation of bed rest.

Secondary outcomes

  1. Change in lower back cross-sectional area

    Time frame: One day before and directly after cessation of bed rest.

  2. Change in leg and whole body lean tissue mass

    Time frame: One day before and directly after cessation of bed rest.

  3. Change in muscle fiber size

    Time frame: One day before and directly after cessation of bed rest.

  4. Change in muscle strength

    Time frame: One day before and directly after cessation of bed rest.

    Measured by 1-Repetition Maximum testing

  5. Change in insulin sensitivity

    Time frame: One day before and directly after cessation of bed rest.

    Measured by hyperinsulinemic-euglycemic clamp

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Official study title

The Impact of Short-term Bed-rest on Skeletal Muscle Mass and Insulin Sensitivity in Healthy, Young Men

Important dates

Study start
2014
Primary completion
2015
First posted
Apr 9, 2014
Registry last updated
Apr 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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