Barotrauma in Adults With Critical COVID-19

During the pandemic of COVID-19, studies reporting a high incidence of barotrauma, both pneumothorax but also pneumomediastinum, in patients with critical COVID-19. If this is complications of the respiratory support used to treat patients hypoxemia or if it is a direct consequence of COVID-19 damaging the lung tissue is not known.

The aim of this study is to investigate the incidence and type barotrauma, if there is an association between barotrauma and level of respiratory support used in the intensive care unit, and if barotrauma is associated with worse outcome compared to patients without barotrauma.

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Key information

Conditions

COVID-19 Barotrauma Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Södersjukhuset

Stockholm, 11883, Sweden

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Positive polymerase chain reaction for SARS-CoV-2
Admitted to ICU due to respiratory failure

Exclusion criteria

Transferred to or from an ICU in other hospital/region making data collection regarding baseline data/outcomes not possible

Treatment and study plan

Open system

Procedure

Oxygen delivered on open system, for example high flow nasal cannula or low flow oxygen by nasal cannula or face mask

Non-invasive mechanical ventilation

Procedure

Respiratory support by for example continues or bilevel positive airway pressure

Invasive mechanical ventilation

Procedure

Respiratory support delivered through endotracheal tube or tracheostomy

Primary outcomes

Barotrauma

Time frame: 28 days from ICU admission

Pneumothorax, pneumomediastinum, pneumatocele or subcutaneous emphysema as verified by radiology

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Registry information

Important dates

Study start: 2020
Primary completion: 2021
Study completion: 2021
First posted: May 26, 2023
Registry last updated: May 30, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed