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Completed

NCT Number: NCT00392561

Bangladesh Vitamin E and Selenium Trial

The purpose of this study is to evaluate whether selenium and/or vitamin E are effective in preventing non-melanoma skin cancers.

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Key information

Conditions

Non-Melanoma Skin Cancer

Age range

25 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Columbia University Arsenic Research Project, Dhaka, Bangladesh

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Manifest arsenic skin lesions (melanosis, leucomelanosis, or keratosis)
  • Aged 25 to 65 years
  • Permanent resident of study area

Exclusion criteria

  • Pregnancy
  • Clinically too ill (enlarged spleen or liver)
  • Presence of gangrene
  • Cancer

Treatment and study plan

Selenium

Dietary Supplement

200 ug Selenium daily

Vitamin E

Dietary Supplement

100 mg Vitamin E daily

Primary outcomes

  1. Skin Cancer

    Time frame: Incidence during the 6-year study period

Secondary outcomes

  1. Mortality

    Time frame: Occurrence during the 6-year study period

  2. Diabetes

    Time frame: Incidence within 6-year study period

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

  • Columbia University
  • Dartmouth-Hitchcock Medical Center
  • International Centre for Diarrhoeal Disease Research, Bangladesh

Registry information

Acronym: BEST

Important dates

Study start
2006
Primary completion
2021
Study completion
2021
First posted
Oct 26, 2006
Registry last updated
Apr 26, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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