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Completed

NCT Number: NCT04430309

Baduanjin on Patients With Schizophrenia

As an ancient, popular Chinese exercise, Baduanjin is characterized by symmetrical posture, deep breathing and meditation and easy to learn. Previous studies showed immediate effect of Baduanjin on cognition in patients with schizophrenia.The purpose of this study is to investigate the immediate effect and chronic effect of Baduanjin exercise on physical fitness, cognition and daily functions in middle-aged and older adults with schizophrenia.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chang Gung Memorial Hospital, Kaohsiung Medical Center

Kaohsiung City, 833, Taiwan

About this study

A single-blind, 2-arm randomized controlled trial investigating the benefits of Baduanjin exercise on middle-aged and older patients with schizophrenia. A total of 48 participants will be assigned to either 12 weeks of 60-minute two sessions per week Baduanjin exercise group or a brisk walking group. Primary outcomes are physical fitness and cognition functions. Secondary outcomes are dual task performance and daily functions. Evaluation will be completed at baseline, immediately after treatment and 4-week follow up.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Having a diagnosis of schizophrenia according to the DSM-5.
  • Independent adult aged 40 years or older in the day-care center.
  • Having a stable mental status without shift in medication and keep in same dose for at least one month.

Exclusion criteria

  • Serious physical conditions that will impede participation, such as cardiovascular disease, musculoskeletal disease or pulmonary system disease.
  • Visual or auditory impairment that precludes completion of assessment.
  • Acute psychosis requiring hospitalization.
  • Presence of severe withdrawal or profound cognitive disability that cause difficulties in following instructions.
  • Participating in another clinical trial at the same time.

Treatment and study plan

Baduanjin Exercise Program

Behavioral

The sessions includes 10-minute warm-up, 40-minute Baduanjin exercise and 10-minute cool down.

Other names: Eight Silken Movements, Eight Silk Weaving

Brisk walking program

Behavioral

The sessions includes 10-minute warm-up, 40-minute brisk walking and 10-minute cool down.

Primary outcomes

  1. Change scores of 6-minute walk test

    Time frame: Baseline, immediate after treatment, 4-week follow up

    This test evaluates cardiovascular fitness and walking speed.

  2. Change scores of 30-second chair stand test

    Time frame: Baseline, immediate after treatment, 4-week follow up

    This test evaluates muscular endurance of lower-extremities.

  3. Change scores of Timed up-and-go test

    Time frame: Baseline, immediate after treatment, 4-week follow up

    This test evaluates functional mobility, agility and balance

  4. Change scores of Montreal cognitive assessment

    Time frame: Baseline, immediate after treatment, 4-week follow up

    This test evaluates global cognition.

  5. Change scores of Trail making test (part A and part B)

    Time frame: Baseline, immediate after treatment, 4-week follow up

    This test evaluates speed of processing, visual attention and cognitive flexibility.

  6. Change scores of Logical Memory

    Time frame: Baseline, immediate after treatment, 4-week follow up

    It is a subtest of the Wechsler Memory Scale. This test evaluates memory.

Secondary outcomes

  1. Change scores of dual task Timed up-and-go test (manual)

    Time frame: Baseline, immediate after treatment, 4-week follow up

    This test requires carry a cup of water 3 cm from the top of the cup while performing the Timed up-and-go test. It evaluates dual task performance.

  2. Change scores of dual task Timed up-and-go test (cognitive)

    Time frame: Baseline, immediate after treatment, 4-week follow up

    This test combine serial three counting and Timed up-and-go test simultaneously. It evaluates dual task performance.

  3. Change scores of Activities of Daily Living Rating Scale III

    Time frame: Baseline, immediate after treatment, 4-week follow up

    It is a self-administered, paper-and-pencil test that evaluates daily functions

Sponsors and collaborators

Lead sponsor

Chang Gung Memorial Hospital

Other

Collaborators

  • National Taiwan University

Registry information

Official study title

The Feasibility and Efficacy of Baduanjin Exercise on Cognition and Physical Fitness Among Patients With Schizophrenia:Randomized Controlled Trial

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jun 12, 2020
Registry last updated
May 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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