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NCT Number: NCT05876598

BACTERIUM: Study for a Machine-learning-based Model to Predict Bloodstream Infections

An increase of healthcare-associated infections caused by multidrug- resistant organisms (MRDO) is currently observed. One of the main causes of the emergence of a MDRO infection is an overuse of antibiotics. Therefore, saving useless antibiotic treatment is currently a priority from a public health point of view. The evaluation of the risk of having a bloodstream infection will allow both activating faster treatment decisions (when the risk is significantly high) or to save useless resources in terms of diagnostic tests and treatments, also limiting the potential for side effects (when the risk is significantly low).

Recruiting

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Key information

Conditions

Infection, Bloodstream Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondazione Policlinico Agostino Gemelli Irccs

Rome, 00168, Italy

Location status: Recruiting

Location contact

RITA MURRI

CONTACT

[email protected]

00390639154945

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patients hospitalized at the Gemelli Polyclinic Foundation
  • having at least one performed blood culture
  • starting an antibiotic therapy

Exclusion criteria

  • blood cultures with contaminants
  • <18 years old
  • died after less than 48 hours from blood cultures positivity

Treatment and study plan

antibiotic treatments

Drug

The outcome of the study will be to implement Prediction Models to support clinicians for the assessment of risk of having a bloodstream infection.

Primary outcomes

  1. Rate of appropriate antibiotic therapy in patients with bloodstream infections

    Time frame: 24 months

    • number of patients with bloodstream infections with appropriate antibiotic therapy before and after the application of the predictive model "Bacterium"

  2. Blood cultures

    Time frame: 24 months

    number of blood cultures done before and after the application of the predictive model "Bacterium"

Study contacts

Contact information is provided by the study sponsor or research team.

rita murri

CONTACT

[email protected]

003930154945

Sponsors and collaborators

Lead sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Other

Registry information

Acronym: BACTERIUM

Important dates

Study start
2021
Primary completion
2025
Study completion
2025
First posted
May 25, 2023
Registry last updated
Mar 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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