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OpenTrials
Completed

NCT Number: NCT03967470

Bacteriotherapy to Improve Underarm Odor

The goal is to improve the underarm odor by changing the microbiome. The autochthonous bacterial community is replaced by a non-smelling microbiome, by daily application of bacteria in a spray.

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Key information

Conditions

Bromhidrosis Body Odor Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Ghent University

Ghent, 9000, Belgium

About this study

Participants are recruited and selected based on their initial underarm odor and underarm microbiome. The participants use two sprays: one spray containing the bacteria, and the other nothing (placebo). Participants do not know which spray they have. They use one spray during one month, and meanwhile take samples of their underarm microbiome (for sequencing), volatome (for GC/MS analysis) and odor (for odor panel analysis). Samples are stored in the freezer and brought to the university after one month, when they receive the second spray. The bacterial spray contains bacteria that are correlated with good underarm odor.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • above average underarm malodor
  • microbiome dominated with malodorous bacteria

Exclusion criteria

  • not healthy
  • microbiome with too high levels of Staphylococcus

Treatment and study plan

Bacterial spray

Biological

Bacterial spray containing bacteria that do not cause underarm malodor

Primary outcomes

  1. Improved underarm odor

    Time frame: 1 month

    Odor panel and GC/MS results provide insights on underarm odor development

Sponsors and collaborators

Lead sponsor

University Ghent

Other

Registry information

Important dates

Study start
2018
Primary completion
2022
Study completion
2022
First posted
May 30, 2019
Registry last updated
Dec 15, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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