Skip to main content
OpenTrials
Completed

NCT Number: NCT01270243

Bacterial Microbiota In The Tonsils Of Children

We, the investigators, propose to look at the bacteria on and in tonsils using gene microarrays. We expect to find previously reported bacteria but also the possibility of previously undetected organisms. We think that the bacterial pathogens present on the tonsillar surface are different from the tonsil core. And we also think that the bacteria of the tonsil surface will differ between patients undergoing adenotonsillectomy and normal controls with no adenotonsillar problems.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Adenotonsillitis

Age range

2 year–12 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Chicago

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Inclusion criteria

for subjects undergoing surgery:

  • Age 2-12 yrs
  • Both males and females
  • Undergoing adenotonsillectomy

Additional criteria for subjects in the recurrent infection group:

  • Sleep questionnaire score <5
  • Designated by surgeon as having recurrent adenotonsillitis as reason for surgery

Additional criteria for subjects in the airway obstruction group:

  • Sleep questionnaire score >5
  • Presence of positive polysomnogram desired but not necessary
  • Designated by surgeon as having airway obstruction or sleep apnea as reason for surgery

Inclusion criteria

for control subjects:

  • Age 2-12 yrs
  • Both males and females
  • No history of adenotonsillar problems
  • Sleep questionnaire score < 5

Exclusion criteria

Exclusion criteria

for both groups:

  • Antibiotic intake in the past 10 days
  • Other major medical problems (immune deficiency, cystic fibrosis, malignancy) In the surgery group: designated by surgeon as having both recurrent adenotonsillitis and airway obstruction as reason for surgery Menstruating females

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Registry information

Official study title

Bacterial Microbiota In The Tonsils Of Children Undergoing Adenotonsillectomy And Normal Controls

Important dates

Study start
2010
Primary completion
2017
Study completion
2017
First posted
Jan 5, 2011
Registry last updated
Apr 26, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.