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OpenTrials
Completed

NCT Number: NCT03919032

Bacterial Infections in Patients with Cirrhosis in Argentina: Clinical and Microbiological Characteristics

In recent years, there has been an increasing prevalence of bacterial infections caused by multiresistant and extremely resistant organisms in patients with cirrhosis. These infections are associated with a worse prognosis, generate difficulties in the management of the patient during hospitalization and increase health costs.

The main objective of this project is to estimate the prevalence of infections by multiresistant bacteria in patients with cirrhosis. Additionally, the prevalence of other antibiotic resistance patterns and morbi-mortality in the study population will be evaluated.

For these purposes, a multicenter prospective cohort study will be carried out, including patients with cirrhosis who present bacterial infections at the time of admission, or during hospitalization.

Performing a study in Argentina on the clinical and microbiological characteristics of bacterial infections in patients with cirrhosis could be very useful to develop new strategies for prevention and treatment of this severe complication.

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Key information

Conditions

Bacterial Infections Bacterial Infections and Mycoses Cirrhosis Fibrosis Infections Morality Pathologic Processes Pathological Conditions, Signs and Symptoms Resistant Infection

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Sebastián Marciano

Buenos Aires, 1643, Argentina

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with cirrhosis
  • Patients older than 17 years.
  • Patients who are hospitalized for bacterial infections, or who develop bacterial infections while hospitalized

Exclusion criteria

  • Refusal to participate in the informed consent process

Treatment and study plan

This is an observational study without intervention

Other

This is an observational study without intervention

Primary outcomes

  1. To estimate the prevalence of infections caused by multi-resistant microorganisms in patients with cirrhosis

    Time frame: at the moment of the diagnosis of the bacerial infection

Secondary outcomes

  1. To evaluate variables associated with infections caused by multi-resistant microorganisms in patients with cirrhosis

    Time frame: at the moment of the diagnosis of the bacerial infection

  2. To evaluate the effect of infections caused by multi-resistant microorganisms on the in-hospital survival of patients with cirrhosis

    Time frame: 30 days

Sponsors and collaborators

Lead sponsor

Hospital Italiano de Buenos Aires

Other

Registry information

Official study title

Bacterial Infections in Patients with Cirrhosis in Argentina

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Apr 18, 2019
Registry last updated
Mar 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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