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Completed

NCT Number: NCT07051837

Background: Isometric Handgrip (IHG) is a Classic Sympatho- Excitatory Stimulus Often Used in Autonomic Testing. Aims: The Aims of This Study Were to Evaluate the Acute Cardiovascular Response and Recovery Following Isometric Handgrip (HG) Exercise-induced Fatigue on Healthy Adults. Secondary, to e

: Isometric handgrip (IHG) is a classic sympatho- excitatory stimulus often used in autonomic testing.

Aims: The aims of this study were to evaluate the acute cardiovascular response and recovery following isometric handgrip (HG) exercise-induced fatigue on healthy adults. Secondary, to examine correlations between isometric handgrip strength and both systolic (SBP) and diastolic (DPB) blood pressure' Methods: Study was a repeated measure single group design. Thirty-five healthy volunteers, 20 females and 15 males, age (36.16 + 6.11years) were enrolled in the study. Study was at out Clinic of October 6 University. Demographic data were collected at beginning of session. Subjects were then assessed for baseline (BL) blood pressure (BP). Maximal isometric voluntary contraction (MIVC) for each subject was the average of two-5 seconds MIVCs of dominant hand using a hand-held dynamometer separated by 1 minute of rest. Subjects were allowed 5 minutes rest, then performed fatigue protocol (FP) using the hand-held dynamometer with their dominant hand at 50% MIVC for 3 minutes as a One minute of rest was given following FP then subjects were reassessed for BP and MIVC of dominant hand respectively (Immediate reassessment). Further, BP was reassessed for 3 times at 5 minutes interval between measures.

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Key information

Conditions

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Amira Mohamed Afify

Giza, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants should fulfil the criteria set for age and BMI ranges. All participants should be medically stable and normotensive. They should not have any physical limitations that prevent performance of IHG exercises.

Exclusion criteria

  • Patients will be excluded from the study if they are smokers, under any medications, diabetics, diagnosed with cardiovascular diseases. Also if they have orthopaedic limitations or mental problems that affect the participation and the result of the study

Treatment and study plan

Primary outcomes

  1. to evaluate the acute cardiovascular response and recovery following isometric handgrip exercise-induced fatigue on healthy adults. and to examine correlations between isometric handgrip strength and both systolic and diastolic blood pressure

    Time frame: from April 2024toMay 2025

    Maximal isometric voluntary contraction (MIVC) for each subject was the average of two-5 seconds MIVCs of dominant hand using a hand-held dynamometer separated by 1 minute of rest. Subjects were allowed 5 minutes rest, then performed fatigue protocol (FP) using the hand-held dynamometer with their dominant hand at 50% MIVC for 3 minutes as a One minute of rest was given following FP then subjects were reassessed for BP and MIVC of dominant hand respectively (Immediate reassessment). Further, BP was reassessed for 3 times at 5 minutes interval between measures

Sponsors and collaborators

Lead sponsor

October 6 University

Other

Registry information

Official study title

Background: Isometric Handgrip (IHG) is a Classic Sympatho- Excitatory Stimulus Often Used in Autonomic Testing. Aims: The Aims of This Study Were to Evaluate the Acute Cardiovascular Response and Recovery Following Isometric Handgrip (HG) Exercise-induced Fatigue on Healthy Adults. Secondary, to Examine Correlations Between Isometric Handgrip Strength and Both Systolic (SBP) and Diastolic (DPB) Blood Pressure' Methods: Study Was a Repeated Measure Single Group Design. Thirty-five Healthy Volunteers, 20 Females and 15 Males, Age (36.16 + 6.11years) Were Enrolled in the Study. Study Was at Out

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jul 4, 2025
Registry last updated
Jul 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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