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OpenTrials
Completed

NCT Number: NCT04433299

Back Pain - Linking Phenotype to Pain Mechanism and Outcome.

To investigate whether different clinical, psychophysical and neurophysiological phenotypes can be identified among low back pain patients

Completed

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Key information

Conditions

Low Back Pain Back Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Balgrist University Hospital

Zurich, Canton of Zurich, 8008, Switzerland

About this study

Low back pain patients will fill in a detailed questionnaire (incl. pain drawing) about their pain. Some of them will undergo a standardized quantitative sensory testing protocol and an fMRI procedure.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-primary complaint: low back pain clinically not attributable to red flags

Exclusion criteria

  • any major medical or psychiatric condition that affects pain sensitivity
  • contraindications to MRI

Treatment and study plan

No intervention, observational

Other

no intervention, observational

Primary outcomes

  1. spatial pain extent

    Time frame: baseline

    spatial pain extent (body map)

  2. measures for central sensitization

    Time frame: baseline

    temporal summation and conditioned pain modulation

Secondary outcomes

  1. changes in spatial pain extent

    Time frame: changes from baseline to 3 months

    changes in spatial pain extent (bodymap)

  2. changes in measures for central sensitization

    Time frame: changes from baseline to 3 months

    changes in temporal summation and conditioned pain modulation

Sponsors and collaborators

Lead sponsor

Balgrist University Hospital

Other

Collaborators

  • University of Zurich

Registry information

Important dates

Study start
2019
Primary completion
2025
Study completion
2025
First posted
Jun 16, 2020
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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