B7-H3 NIR Imaging for Osteosarcoma Surgery

Inclusion criteria

• 1. Patients with histologically confirmed osteosarcoma of the limbs.
• 2. the patients has not undergone tumor resection.
• 3. Age between 18 and 60 years old.
• 4. No prior systemic treatment for osteosarcoma.
• 5. Measurable disease as assessed by imaging studies (e.g., MRI, CT).
• 6. Adequate bone marrow, liver, and renal function.
• 7. Written informed consent obtained from the patient.

Exclusion criteria

• 1. History of other malignancies within the past 5 years.
• 2. Pregnancy or lactation.
• 3. Known hypersensitivity to any component of the B7H3-based NIR imaging agent.
• 4. Uncontrolled intercurrent illness that would preclude safe study participation.
• 5. Prior radiation therapy to the target lesion.
• 6. Any medical condition that would compromise the patient's ability to undergo surgery or comply with study procedures.
• 7.Patients not able to sign the Informed Consent.