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OpenTrials
Completed

NCT Number: NCT06891170

B Cell Responses in COVID-19

In this study, we will develop techniques to optimize the in vitro production of human monoclonal antibodies.

Completed

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Key information

Conditions

COVID 19 COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondazione IRCCS Policlinico San Matteo di Pavia

Pavia, 27100, Italy

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age >18 at time of signing informed consent form
  • Signed informed consent form

Exclusion criteria

  • Ongoing drug abuse
  • Active or history of neoplastic malignancy
  • Active autoimmune disease ongoing treatment with immunosuppressive therapy
  • Ischemic heart disease
  • Evidence of positive HIV, HCV, HBV test
  • Diabetes
  • Failure to sign informed consent form

Treatment and study plan

Primary outcomes

  1. Optimization of the method to obtain human mAbs neutralizing COVID-19.

    Time frame: From enrollment to 24 weeks

Sponsors and collaborators

Lead sponsor

Fondazione IRCCS Policlinico San Matteo di Pavia

Other

Registry information

Official study title

B Cell Responses in COVID-19: Generation of SARS-CoV-2 Neutralizing Human Monoclonal Antibodies to Efficiently Contrast Wild-type and Emerging Variants.

Important dates

Study start
2021
Primary completion
2024
Study completion
2025
First posted
Mar 24, 2025
Registry last updated
Apr 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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