Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
Location status: Recruiting
Recruiting
NCT Number: NCT03991663
Azoospermia Patients
The Prospective Cohort Study for Azoospermia Patients was set up to investigate the short- and long-term health consequences in Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, China.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year–40 year
Sex eligibility
Male
Study type
Observational
Primary location
About this study
Infertility is an important problem with a multifactorial etiology that affects approximately 15% of couples who attempt pregnancy. Its cause in approximately 50% of infertile couples is male factors. Spermatogenesis is an extremely complex cell differentiation process involving 2,300 genes that regulate germ cell development and maturation.
Since last decade, Clinical Reproductive Medicine Management System/Electronic Medical Record Cohort Database (CCRM/EMRCD) has been used in Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, and Henan Province Key Laboratory for Reproduction and Genetics. Information of patients (POI, PCOS, Endometriosis, azoospermia, ect) were recorded comprehensively. The current project plans to recruit azoospermia participants in our center. Biological samples, questionnaires and short/long term health data will be collected. The study is aimed to provide evidence for azoospermia prognosis.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- at least three semen evaluations performed on separate occasions, when the seminal specimen after centrifugation showed no sperm under the microscope and was then diagnosed according to several clinical parameters；
Exclusion criteria
-
Treatment and study plan
Primary outcomes
-
Level of serum FSH (Follicle stimulation hormone)
Time frame: From date of inclusion, assessed by each 12 month, up to 40 years
mIU/mL
-
Level of serum LH (luteinizing hormone)
Time frame: From date of inclusion, assessed by each 12 month, up to 40 years
mIU/mL
-
Level of serum T (Testosterone)
Time frame: From date of inclusion, assessed by each 12 month, up to 40 years
ng/ml
Secondary outcomes
-
Volume of testicles
Time frame: From date of inclusion, assessed by each 12 month, up to 40 years
Record the Length (mm)*Width (mm) of each testicle
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
The First Affiliated Hospital of Zhengzhou University
Other
Registry information
Official study title
Prospective Cohort Study for Azoospermia Patients in Clinical Reproductive Medicine Management System/Electronic Medical Record Cohort Database (CCRM/EMRCD)
Important dates
- Study start
- 2010
- Primary completion
- 2050
- Study completion
- 2050
- First posted
- Jun 19, 2019
- Registry last updated
- Jun 19, 2019
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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