Azilsartan in Chinese Patients With Mild and Moderate Hypertension

Inclusion criteria

• 18-70 years of age (including 18 and 70 years of age), male or female;
• diagnosed with mild to moderate essential hypertension;
• clinic diastolic and systolic blood pressure need to meet the following two conditions: 3 times mean sitting diastolic blood pressure measurements at 95mmHg-110mmHg (not including 110mmHg); 3 times sitting systolic blood pressure measured and mean value between150mmHg-180mmHg (not including 180mmHg);
• understand clearly that voluntary to participate in the study, sign informed consent.

Exclusion criteria

• severe essential hypertension (sitting systolic ≥180mmHg and / or sitting diastolic pressure ≥110mmHg), malignant hypertension, hypertensive emergency, hypertensive crisis and high blood pressure encephalopathy.
• secondary hypertension.
• The following hypertension and diseases: acute myocardial infarction within 6 months, the cerebral artery accident, transient ischemic attack; or dissecting aortic aneurysm, angina, II-IVClass (NYHA classification) history of heart failure Ⅱ degree atrioventricular block, sick sinus integrated disease, bradycardia (heart rate <50 beats / min) or other antiarrhythmic drugs needed.
• significant laboratory abnormalities include: serum potassium> 5.5mmol / L; blood ALT or AST> 2.5ULN; serum creatinine> 1.5ULN.
• unilateral or bilateral renal artery stenosis.
• Type 1 diabetes and poor glycemic control of type 2 diabetes (HbA1c values ≥ 8%).
• gastrointestinal lesions or gastrointestinal surgery may affect drug absorption or excretion, such as stomach-bowel resection, nearly one year activity of gastrointestinal inflammation, ulcers or gastrointestinal bleeding.
• azilsartan sheet or olmesartan medoxomil tablets and related drugs (ARB, ACEI And renin inhibitors) allergies.
• pregnant, lactating female patients, or during the test does not guarantee the effective collision pregnant person.
• Obesity, body mass index (BMI)> 30kg / m2.
• Import of use in addition to import other types of medication trials of antihypertensive drugs, Anti-angina drugs, lithium agents, corticosteroids, licorice, estrogen, digitalis Drugs and drugs were potassium.
• Variance of diastolic blood pressure ≥8mmHg.
• drug or alcohol abuse within 6 months Are drinking more than two units of alcohol (1 unit = 360mL or 45mL alcohol content of 40%).

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