Skip to main content
OpenTrials
Completed

NCT Number: NCT04146558

Ayurvedic Treatment Package in Plaque Psoriasis

Psoriasis is a chronic, immune-mediated inflammatory skin disease that is associated with substantial impairment of physical and psychological quality of life. The conventional treatment protocols manages the condition but with remissions and relapses which create anxiety in patients. Many of the patients withdraw from active social life as the disease attains chronicity. Several studies are pointing towards a conjoint management strategy incorporating the traditional and alternate medical systems. In this regard, Ayurveda is commonly used by psoriatic patients in India. Considering this fact it is high time to conduct a study to scientifically evaluate the efficacy of Ayurvedic treatment protocol in managing psoriasis as well as its potential to improve the quality of life.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Psoriasis Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

PNNM Ayurveda College

Shōranūr, Kerala, 679 531, India

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with psoriasis having age 18 years or more
  • Patients with moderate-to-severe plaque psoriasis with a PASI score of 12 or higher
  • Psoriasis diagnosed 6 months or more before study entry
  • Those who are poorly controlled based on physicians assessment with topical treatments, phototherapy, systemic therapy, or a combination of these therapies.
  • Participants who have given informed consent.

Exclusion criteria

  • Participants with other systemic illnesses
  • Lactating and pregnant mothers.
  • Alcohol dependence/Narcotic dependence /Steroid dependence
  • In the judgment of the investigator, unable or unwilling to follow the protocol and instructions

Treatment and study plan

Individualized internal ayurvedic treatment

Drug

All possible internal preparations will be administered for a period of 12 months.

All administered preparations with its dosage and duration will be documented All preparations will be subjected to lab test for clearing heavy metal and pesticide content before the administration

External ayurvedic treatment

Other

Application of warm external oil (Ayyapala kera tailam) on affected parts twice daily

Primary outcomes

  1. Psoriasis-specific quality of life

    Time frame: 6 months

    Psoriasis specific DLQI scores

Secondary outcomes

  1. Psoriasis Severity

    Time frame: 3 months

    Psoriasis Area Severity Index (PASI) score

  2. Psoriasis Severity

    Time frame: 6 months

    Psoriasis Area Severity Index (PASI) score

  3. Psoriasis Severity

    Time frame: 12 months

    Psoriasis Area Severity Index (PASI) score

  4. Psoriasis-specific quality of life

    Time frame: 3 months

    Psoriasis specific DLQI scores

  5. Psoriasis-specific quality of life

    Time frame: 12 months

    Psoriasis specific DLQI scores

  6. Adverse events

    Time frame: 3 months

  7. Adverse events

    Time frame: 6 months

  8. Adverse events

    Time frame: 12 months

Sponsors and collaborators

Lead sponsor

Universität Duisburg-Essen

Other

Collaborators

  • Poomulli Neelakandan Namboodiripad Memorial Ayurveda Medical College

Registry information

Official study title

A Randomized Open Label Clinical Trial on the Efficacy of an Ayurvedic Treatment Package on Symptom Severity and Quality of Life in Plaque Psoriasis

Important dates

Study start
2019
Primary completion
2023
Study completion
2023
First posted
Oct 31, 2019
Registry last updated
Jun 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.