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Completed

NCT Number: NCT05866289

Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure

The objective of our study is to evaluate the effectiveness of prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.

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Key information

Conditions

Survival, Prosthesis COVID-19 Coronaviridae Infections Coronavirus Infections Hypoxia Infections Lung Diseases Nidovirales Infections Oxygen Deficiency Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral Postoperative Complications Prosthesis Failure RNA Virus Infections Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases Respiratory Tract Infections Signs and Symptoms Signs and Symptoms, Respiratory Virus Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Amine Elmouhib

Oujda, 60000, Morocco

About this study

The COVID-19 pandemic has challenged the management of hypoxemic respiratory failure as limited ICU capacity is strained by a new high-mortality disease and large numbers of patients requiring prolonged periods of hospitalization, as well as respiratory support equipment such as ventilators and intensive care unit (ICU) beds.

If early and prolonged prone positioning (DV) reduces mortality in invasively ventilated patients with acute respiratory distress syndrome (ARDS), its role in conscious patients (DV vigil) remains a subject of debate and research.

This is a retrospective, monocentric, descriptive and analytical cohort conducted over a period of 22 months from March 2020 to December 2021 and involving 1069 patients hospitalized in the intensive care unit of the CHU Mohammed VI of Oujda for the management of acute respiratory failure caused by COVID-19.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all patients (1069 patients) with ARDS due to SARS-cov2, confirmed by nasopharyngeal swab, who were hospitalized in the COVID-19 ICU from March 1, 2020 to December 31, 2021

Exclusion criteria

  • Patients with negative CRP
  • Younger than 18 years of age
  • Patients who died or intubated on the day of admission
  • Patients presented a contraindication

Treatment and study plan

Prone position

Other

Each prone position session had a minimum duration of one hour and a maximum duration of 12 hours for a minimum of 3 hours per day.

Primary outcomes

  1. Evaluate the effectiveness of awake prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.

    Time frame: 22 months

    Evaluate the effectiveness of awake prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.

Secondary outcomes

  1. length of stay in intensive care unit, length of time from hospitalization to death, length of time from hospitalization to intubation.

    Time frame: 22 months

    length of stay in intensive care unit, length of time from hospitalization to death, length of time from hospitalization to intubation.

Sponsors and collaborators

Lead sponsor

Mohammed VI University Hospital

Other

Registry information

Official study title

Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure: Retrospective Cohort Study

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
May 19, 2023
Registry last updated
May 19, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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