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NCT Number: NCT01463761

Autonomic Nervous System, Fatigue and Intolerance to Physical Training, and Overtraining in High-Level Athletes

Sports training aims to enhance an athlete's performance (overcompensation). To do that, the athlete must go through periods of fatigue and lower performance (overreaching). When the training plan is balanced, this fatigue is short and reversible.If the training load is too heavy or if recuperation periods are too short, it can lead to persistence fatigue that may only be reversible in the long term. This state of fatigue is part of the broader clinical picture of overtraining, which includes stark changes in performance as well as mood and sleep disorders. Many prediction and characterization methods based on biological markers have been evaluated, but they have not been put into practice in sports training due to obstacles such as reliability, interindividual variability and high costs. This study aims to evaluate a new approach based on the variability of an individual's heart rate (RR variability), which is a way of measuring autonomic nervous system (ASN) activity. It is non-invasive, low-cost, and has already proven useful in athlete health monitoring.

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Key information

Age range

14 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CH Albertville Moutiers, Albertville, France

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About this study

The investigators propose to describe the variation of these ANS regulation factors over a full year, in a population of high-level athletes, in order to measure changes in regulation which may be predictive of potential fatigue and intolerance to physical training, if such a syndrome came to be observed among the study group.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • High-level athlete, enrolled in a Ministry-recognized Pôle
  • Participant signed the informed consent form

Exclusion criteria

  • Confirmed current overtraining syndrome
  • Known pregnancy on inclusion
  • Athlete using cardio-inhibitor or cardio-accelerator drugs

Treatment and study plan

ANS activity

Device

This ANS activity is measured by nocturnal heart rates records with Holter ECG.

Primary outcomes

  1. Autonomic nervous system (ANS) activity

    Time frame: One year

    This ANS is mesured during the night using a spectral analysis of nocturnal heart rate variability.

  2. Fatigue and physical training

    Time frame: One year

    Fatigue and physical training potetially due to overtraining, suspected based on a very significant, long-term worsening in performance

Secondary outcomes

  1. kinetic of the ANS activity

    Time frame: Every 15 days (from the iclusion to one year)

    ANS is mesured during the night using a spectral analysis of nocturnal heart rate variability

  2. orthostasis test

    Time frame: Every 15 days (from inclusion to one year)

    ANS activity measurements (RR variability) during active orthostasis transition on waking up in the morning

  3. French Society of Sports Medicine questionnaire

    Time frame: Every 15 days (from inclusion to one year)

    The questionnaire was designed to detect early signs of overtraining. It includes 54 yes/no questions. Subjects who answer "yes" to more than 20 questions are considered at risk for overtraining.

  4. POMS (Profile of Mood States) questionnaire

    Time frame: Every 3 months (from inclusion to inclusion)

  5. Sleep quality questionnaire

    Time frame: Every 3 months (from inclusion to one year)

    The questionnaire is self-administered. It includes two parts. The first part consists of several questions regarding sleep during the previous night. The second part aims to evaluate the physical exertion load during the previous day's training session(s). Participants will fill one questionnaire/day for a whole week. Each questionnaire period must coincide with a training period (interseason, volume, intensity, or competition.)

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Collaborators

  • Minister of Youth Affairs and Sports, France

Registry information

Official study title

Autonomic Nervous System, Fatigue and Intolerance to Physical Training, and Overtraining in High-Level Athletes. A Multicentre Study

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
Nov 2, 2011
Registry last updated
Mar 6, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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