Skip to main content
OpenTrials
Completed

NCT Number: NCT01833429

Autonomic Dysfunction in Resistant Hypertension

The contribution of this study is the unedited evaluation of the circadian autonomic profiles of resistant hypertension with and without white-coat response.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hypertension, Resistant to Conventional Therapy Hypertension Resistant to Conventional Therapy

Age range

30 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cardiovascular Pharmacology Laboratory

Campinas, São Paulo, 13083-888, Brazil

About this study

All patients were submitted to office blood pressure measurement, Ambulatory blood pressure monitoring and 24-hour Holter monitoring.

Baseline blood samples for the measurement of glycemia (mg/dL), total cholesterol (mg/dL), LDL cholesterol (mg/dL), triglycerides (mg/dL), creatinine (mg/dL), serum uric acid, serum sodium, serum potassium, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were collected at 08:00 after overnight fasting.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • resistant hypertensive patients

Exclusion criteria

  • White-coat hypertension
  • obstructive sleep apnea

Treatment and study plan

Primary outcomes

  1. evaluation of the autonomic function in resistant hypertensive patients

    Time frame: 10 months

    The autonomic nervous system can be assessed by the heart rate variability. Variations in heart rate variability are normally observed in association with diurnal rhythms and blood pressure changes. The heart rate variability parameters are different in many studies, although the consensus is that lower values of the indices of vagal as well as high indices of sympathetic functions are associated prospectively with death and disability.

    In humans, the disturbances of the circadian rhythms of heart rate variability and blood pressure have been intensively studied, mainly due to the increased cardiovascular death reported during the morning hours

Sponsors and collaborators

Lead sponsor

University of Campinas, Brazil

Other

Registry information

Official study title

Circadian Autonomic Disturbances in Resistant Hypertension With and Without White-coat Phenomenon

Acronym: RH

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Apr 16, 2013
Registry last updated
Apr 16, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.