Autonomic and Metabolic Response to Cardiac Rehabilitation After Acute MI

Ischemic heart disease remains the leading cause of death in the western world. The beneficial effects of cardiac rehabilitation on the evolution of ischemic heart disease are known, but the effects of rehabilitation on the metabolic processes of the patients are so far poorly understood. Metabolomics is the qualitative/quantitative analysis of the body's metabolic responses to pathophysiological stimuli or genetic alterations. Metabolic changes caused by physical activity have been demonstrated in obese and diabetic patients and in athletes. Aim of the study is to evaluate whether cardiac rehabilitation after a first myocardial infarction induces changes in the metabolic state of patients, and whether these changes may be related with changes in the usual risk factors (i.e. glyco-lipidic profile, natriuretic peptides, homocysteine).

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Key information

Conditions

Acute Myocardial Infarction: Rehabilitation Phase Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

25 year–75 year

Sex eligibility

Male

Study type

Observational

Primary location

Istituto Auxologico Italiano

Milan, 20149, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

recent first acute myocardial infarction

Exclusion criteria

severe diabetes

Treatment and study plan

Cardiac rehabilitation

Other

Six weeks of cardiac rehabilitation with physical training

Primary outcomes

Changes in purine after rehabilitation

Time frame: Baseline and after 6 weeks of rehabilitation

The concentration of purine will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis.
Changes in histidine after rehabilitation

Time frame: Baseline and after 6 weeks of rehabilitation

The concentration of purine will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis
Changes in galactose after rehabilitation

Time frame: Baseline and after 6 weeks of rehabilitation

The concentration of galactose will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis.

Sponsors and collaborators

Lead sponsor

Istituto Auxologico Italiano

Other

Registry information

Official study title

Autonomic and Metabolic Response to Cardiac Rehabilitation After Acute Myocardial Infarction

Acronym: RIABILITOMICA

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2025
First posted: Mar 7, 2024
Registry last updated: Aug 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed