Automating Breast Radiation Therapy (RT)

Breast radiation treatment is planned from a Computed Tomography (CT) scan. This study is designed to investigate a method to reduce the time between the planning of radiation treatment and its actual start by automating the intensity-modulated radiation therapy (IMRT) planning process. The investigators plan to examine data from another scan called Cone Beam Computed Tomography (CBCT). A CBCT scan provides similar information to a conventional CT scan, however the images for CBCT are acquired at the treatment unit (linear accelerator used for treatment). Using these x-ray pictures of patients, the study team consisting of a radiation oncologist, a medical physicist and a radiation therapist will create a custom treatment plan unique to each patient. By doing this, the investigators hope to reduce the amount of time spent waiting for treatment and the number of hospital visits for patients in the future.

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Key information

Conditions

Breast Cancer Breast Diseases Breast Neoplasms Neoplasms Neoplasms by Site Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

University Health Network, Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with breast cancer who will receive standard two-field tangential whole breast radiation therapy with dose prescription of 4240 cGy in 16 fractions, 5000 cGy in 25 fractions or 4000 cGy in 16 fractions.
Patients with any stage of breast cancer.
Patients with prior treatment such as surgery or chemotherapy for any type of cancer.
Able to provide a written informed consent.
18 years of age or older.

Exclusion criteria

< 18 years of age.
Unable to provide informed consent.
Males.
Patients who received partial breast radiation and not the standard dose.
Patients who will not receive 4240 cGy in 16 fractions, 5000 cGy in 25 fractions, or 4000 cGy in 16 fractions.

Treatment and study plan

Cone Beam CT

Procedure

Patients will also have a CBCT scan when they are having their first IMRT treatment.

Primary outcomes

To generate on-line IMRT treatment plans using automated tools based on CBCT images acquired at the treatment unit.

Time frame: 3 years

Sponsors and collaborators

Lead sponsor

University Health Network, Toronto

Other

Collaborators

Princess Margaret Hospital, Canada

Registry information

Official study title

Automating the Breast Radiation Therapy Process to Improve Efficiency

Important dates

Study start: 2009
Primary completion: 2015
Study completion: 2016
First posted: Jun 18, 2009
Registry last updated: Oct 18, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed