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Enrolling by Invitation

NCT Number: NCT07397260

Automatically Transmitted Home Blood Pressure and Automated Patient Feedback in Hypertension Care: the AUTO 2 Trial

The purpose of this study is to evaluate the effectiveness of automatically-generated medical advice to patients about to their home blood pressure monitoring results sent through patient portal messages compared to no automated advice and the effectiveness of automated transmission of remotely-obtained blood pressure values compared to self-reported values on systolic blood pressure at 1-year follow up in patients with uncontrolled hypertension whose physicians or advance practice providers provide primary care at Northwestern Medicine. Persistence of effects through 18 months will also be assessed.

Enrolling by Invitation

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Key information

Age range

18 year–84 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Northwestern University Feinberg School of Medicine

Chicago, Illinois, 60611, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-84 years at enrollment date
  • Receives hypertension care primarily from a participating clinician
  • Blood pressure on the two most recent days when ambulatory clinic blood pressure was obtained prior to patient identification to was ≥140 mm Hg systolic and/or ≥90 diastolic or last ambulatory clinic blood pressure was ≥150 mm Hg systolic and/or ≥95 diastolic
  • Currently has or is willing to obtain a patient portal account from NM.

Exclusion criteria

  • Dementia,
  • Nursing home resident,
  • Stage 5 chronic kidney disease or renal replacement therapy,
  • Pregnancy,
  • Receiving hospice,
  • Not planning to continue to receive hypertension care from NM clinician for the next year,
  • Planning to move from the region in the next year,
  • Planning to change clinician treating their hypertension in the next year,
  • Medical or psychological reason they cannot perform home blood pressure monitoring.
  • Known to have average home blood pressure or most recent home blood pressure value of <130/80 mm Hg.

CLINICIAN PARTICIPANT INCLUSION Physician, advanced practice nurse or physician assistant working at a Northwestern Medicine ambulatory primary care site that cares for adults with hypertension (family medicine, internal medicine, medicine/pediatrics, and ambulatory geriatrics sites).

CLINICIAN PARTICIPANT EXCLUSION

  • Primary care physicians and clinicians not willing for their patients to participate in study
  • Planning to depart NM within the next year
  • Not willing to receive patients' out-of-office blood pressure data

Treatment and study plan

Self report of home measured blood pressure via patient EHR portal

Other

Participants will be provided with a home blood pressure monitor and method to use the EHR portal to enter home collected blood pressures into the EHR.

Automated feedback about home blood pressure results

Other

Patients will received periodic messages about the results of their home blood pressure monitoring with suggestions to consult with clinical care team when indicated.

Automated Transmission of Remotely Measured Blood Pressure

Other

Participants will be provided with a blood pressure monitor and application to automatically transmit home blood pressures to their EHR record.

Primary outcomes

  1. Systolic blood pressure at 12 months

    Time frame: 12 months

Secondary outcomes

  1. Systolic blood pressure at 18 months

    Time frame: 18 months

  2. Antihypertensive medication changes from baseline

    Time frame: From baseline to 12 months and 18 months

  3. Antihypertensive medication classes prescribed, standardized count

    Time frame: 12 months and 18 months

  4. Medication adherence (patient report, Domains of Subjective Extent of Nonadhernece)

    Time frame: 12 months and 18 months

  5. Diastolic blood pressure

    Time frame: 12 months and 18 months

  6. Blood pressure <130/80 mm Hg

    Time frame: 12 months and 18 months

  7. Blood pressure <140/90 mm Hg

    Time frame: 12 months and and 18 months

Other outcomes

  1. Patient engagement (Consumer Health Activation Index)

    Time frame: 12 months and 18 months

  2. Quality of Life (PROMIS® Scale v1.2 -Global Health)

    Time frame: 12 months and 18 months

  3. Office encounters count

    Time frame: From baseline to 12 months and 18 months

  4. Portal messages count

    Time frame: From baseline to 12 months and 18 months

  5. Telephone encounters count at 1 year and 18 months

    Time frame: From baseline to 12 months and 18 months

Sponsors and collaborators

Lead sponsor

Northwestern University

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Official study title

Effects of Manually Recorded or Automatically Transmitted Home Blood Pressures With or Without Automated Patient Feedback on Hypertension Care

Acronym: AUTO 2

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Feb 9, 2026
Registry last updated
May 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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