Automated Retinal Image Analysis System (EyeQuant) for Computation of Vascular Biomarkers

This study aims to provide clinical validation of EyeQuant, a fully automated retinal image analysis system for computation of vascular biomarkers indicative of cognitive disorders, using retinal fundus photographs collected from patients with mild cognitive impairment, Alzheimer's disease, and vascular dementia.

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Key information

Conditions

Mild Cognitive Impairment Alzheimer Disease Arterial Occlusive Diseases Arteriosclerosis Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Cognition Disorders Cognitive Dysfunction Dementia Dementia, Vascular Intracranial Arterial Diseases Intracranial Arteriosclerosis Leukoencephalopathies Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies Vascular Dementia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Mayo Clinic Arizona

Scottsdale, Arizona, 85259, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients older than 18 years and diagnosed with mild cognitive impairment (MCI), Alzheimer's disease (AD), or vascular cognitive impairment and/or dementia (VaD).

Exclusion criteria

Children and subjects with other diagnoses than those mentioned in the inclusion criteria.
Patients without the means to visit the clinic on the assigned dates.
Patients who are pregnant or are expecting to become pregnant.

Treatment and study plan

Retinal fundus photography

Diagnostic Test

Fundus photographs

Primary outcomes

retinopathy features identification

Time frame: 12 months

The retinal vascular parameters computed using EyeQuant will be compared against the current gold-standard, based on expert annotations

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

Eyenuk, Inc.
Kaushal Solanki
Malavika Bhaskaranand PhD

Registry information

Official study title

Clinical Validation of an Automated Retinal Image Analysis System (EyeQuant) for Computation of Vascular Biomarkers Indicating Cognitive Decline

Important dates

Study start: 2020
Primary completion: 2021
Study completion: 2021
First posted: Sep 28, 2020
Registry last updated: Nov 1, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed