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NCT Number: NCT05278390

Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure: Application to the COVID-19 Pandemic

Automated quantification of the pulmonary volume impaired during acute respiratory failure could be helpful to assess patient severity during COVID-19 infection or perioperative medicine, for example.

This study aims at assessing the correlation between the amount of radiologic pulmonary alteration and the clinical severity in two clinical situation :

1. SARS-CoV-2 infections 2. Postoperative hypoxemic acute respiratory failure.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

SARS-CoV-2 Infections COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Failure With Hypoxia Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Service d'anesthésie réanimation-CHU de Nancy, Nancy, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subject admitted to a care unit of the University Hospitals of Strasbourg or the University Hospital of Nancy and presenting a suspicion of SARS-CoV-2 infection or postoperative hypoxemic respiratory failure
  • Able to understand the objectives and risks of the research and to give dated and signed informed consent.

Subjects may also be included in emergency or immediate life-threatening situations.

  • Subject with insurance covering

Exclusion criteria

  • Pregnant woman (pregnancy confirmed by a urine or blood test)
  • Subject usually on home oxygen therapy
  • Subject under court protection
  • Subject under guardianship or curatorship

Treatment and study plan

Thoracic CT scan

Radiation

Automated quantitative analysis of altered pulmonary volume

Primary outcomes

  1. Correlation between altered pulmonary volume and ordinal severity scale

    Time frame: 2 days after CT scan (Day 2)

    This criterion will be expressed as a score between 1 (least severe) and 7 (most severe).

Secondary outcomes

  1. Correlation between altered pulmonary volume and ordinal severity scale

    Time frame: 7 days after CT scan (Day 7)

    This criterion will be expressed as a score between 1 (least severe) and 7 (most severe).

  2. Mortality

    Time frame: 90 days following CT scan (Day 90)

  3. Rate of admission to intensive care unit

    Time frame: 28 days following CT scan (Day 28)

  4. Initial length of hospitalization stay (in days)

    Time frame: 90 days following CT scan (Day 90)

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Collaborators

  • E-MEDIA
  • REGION GRAND EST
  • VISIBLE PATIENT

Registry information

Official study title

Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure: Application to the COVID-19 Pandemic : Prospective Multicenter Cohort Study

Acronym: QUANTICO-PRO

Important dates

Study start
2022
Primary completion
2025
Study completion
2027
First posted
Mar 14, 2022
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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