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OpenTrials
Active, Not Recruiting

NCT Number: NCT06715488

Automated Arthritis Detection Using Artificial Intelligence on Smartphone Photographs

The investigators are testing the ability of convolutional neural networks (CNNs), that is artificial intelligence, on smartphone photographs in detecting inflammatory arthritis. This promises to be an efficient, accurate, and non-invasive diagnostic tool that will significantly improve early detection and management of inflammatory arthritis.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Rheumatology Clinic, Pune, Maharashtra, India

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About this study

Over the past 4 years the investigators have aimed to help the early detection of arthritis leveraging artificial intelligence. This project aims to detect arthritis based on smart phone photographs of joint areas that make it scalable and available in the community. This group first developed a compelling proof-of-concept pipeline and models using 100 patients. (published in Frontiers in Medicine, Nov 2023, wherein they demonstrated that this technology works with reasonable accuracy in the lab, viz Technology Readiness Level currently stands at 3-4). They followed with a newer paper (submitted for publication, available on preprint server MedRxiv) that trained two different CNNs, a screening CNN on uncropped hands that distinguishes patients from controls followed by joint specific detections.

The system involves supporting infrastructure that will enable efficient detection of arthritis. This includes

  • Collection of photos in a standardized manner using custom designed boxes
  • Using and testing a browser pipeline
  • The CNN models will be trained on the dataset of photographs taken in this and results will be deployed to doctors in the community. This ensures a doctor in the loop that can later take action on the results for further confirmatory tests or management.
  • Understanding knowledge, attitude of patients and doctors towards AI in clinical decision making algorithms

This is a Prospective, non-interventional study and this project only involves an investigator taking a smartphone photograph of some joint areas kept in standardized positions. This involves no risk to the patient.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Inflammatory arthritis of any etiology

Exclusion criteria

  • Severe deformity that hampers standardization of photographs

Treatment and study plan

AI assisted smartphone diagnosis

Diagnostic Test

Patients will examination and clinical photographs for convolutional networks to diagnose inflammatory arthritis

Primary outcomes

  1. Accuracy of AI diagnosis against specialist (rheumatologist) opinion

    Time frame: 3 years

    Concordance of detection of synovitis by convolutional neural network (binary) with a clinically diagnosed specialist opinion (rheumatologist opinion)

Secondary outcomes

  1. Accuracy of AI diagnosis against imaging diagnosis on Ultrasound

    Time frame: 3 years

    Concordance of detection of synovitis by convolutional neural network (binary) compared to musculoskeletal ultrasound

  2. Sensitivity to change

    Time frame: 3 years

    Can the convolutional neural network detect change from an inflamed to an non-inflamed joint

Sponsors and collaborators

Lead sponsor

Med2Measure

Industry

Collaborators

  • IISER Pune

Registry information

Official study title

Automated Detection Methods for Inflammatory Arthritis and Formation of an Image Database

Acronym: AISynovitis

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Dec 4, 2024
Registry last updated
Dec 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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