Autologous Mesenchymal Stem Cells From Adipose Tissue in Patients With Secondary Progressive Multiple Sclerosis

Inclusion criteria

• Patients diagnosed with Multiple Sclerosis (Poser and McDonald criteria).
• Secondary progressive MS patients with EDSS ≥ 5.5 and ≤ 9.
• Patients with treatment failure defined by: no response to immunomodulators / immunosuppressants, and showing activity in the form of 1 relapse in the last year or 0.5 points in EDSS progression.
• Patients with no MS relapse and no steroid treatment within the month prior to inclusion.
• Patients who give written consent to participate in the study. -

Exclusion criteria

• History of current pathology or current laboratory results indicative of any severe disease.
• Pacemaker or metallic implants that prevent MR imaging.
• Inability to complete questionnaires.
• Refusal to give informed consent.
• Predicted impossibility for a biopsy of at least 30 grams of fat tissue.
• Positive screening test for HIV, Hepatitis B or Hepatitis C.
• History of malignancy.
• Having been in treatment with any investigational drug or have undergone any experimental procedure in the 3 months prior to baseline.
• Body mass index> 40 kg/m2.
• Patients who have been treated with prohibited concomitant medication during the month prior to inclusion in the study.
• Pregnancy or lactation

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