Auditory Verbal Hallucinations in Schizophrenia

Auditory verbal hallucinations (AVHs) are speech perceptions in the absence of a relevant external stimulation. Some accounts of AVHs claim that a deficit in inner speech monitoring would cause the verbal thoughts of the patient to be perceived as external voices resulting in AVHs.

In order to examine whether AVHs correspond to self-generated inner speech, the present study aims at collecting speech muscle activity during covert AVHs (without articulation), overt speech and rest. Surface electromyography (sEMG) is used on schizophrenia patients and control subjects to detect any speech muscle activity during AVH.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital of Grenoble

Grenoble, 38043, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy controls:

must be more than 18 years and less than 60 years old
pre-inclusion medical examination
must have signed consent form
must be able to read stimuli on a screen

Schizophrenia patients:

must be more than 18 years and less than 60 years old
pre-inclusion medical examination
must have signed consent form
must be able to read stimuli on a screen
diagnosed with a schizophrenia disorder according to DSM-IV TR (diagnostic and statistical of mental disorders) (PANSS item P3 greater than 4)
prior evaluation of the secondary effects of any medication via Barnes and AIMS scales
affiliated with the French social security
if under guardianship, must have additional consent form signed by guardian

Exclusion criteria

Healthy controls:

if aged less than 18 years or more than 60 years
diagnosed with any psychiatric disorder
with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.)
with auditory impairment
pregnant, parturient, breast-feeding

Schizophrenia patients:

if aged less than 18 years or more than 60 years
significant secondary effects of antipsychotic medication, measured with the Barnes and AIMS scales
with a neurodegenerative disease
with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.)
with auditory impairment
pregnant, parturient, breast-feeding

Treatment and study plan

Primary outcomes

Labial EMG activity during auditory verbal hallucination

Time frame: up to 3 years

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Collaborators

GIPSA-LAB

Registry information

Official study title

Electromyography Study of Lip Muscles During Auditory Verbal Hallucinations Without Subvocalization in Patients With Schizophrenia

Acronym: HAV

Important dates

Study start: 2009
Primary completion: 2015
Study completion: 2015
First posted: Jun 25, 2013
Registry last updated: Mar 10, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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