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Completed

NCT Number: NCT02791997

Audition After a Lesion and in Migraine. (AuditionPostLesion)

The project studies auditory processing after brain damage (in temporal and/or frontal areas) and in migraine. The auditory processes investigated are attention, short-term memory, sound-induced emotions. To characterize auditory deficits after brain damage or in migraine, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).

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Key information

Conditions

Migraine Disorders, Brain Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Headache Disorders Headache Disorders, Primary Migraine Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Unité 201, Hôpital Neurologique, Bron, France

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age from 18 to 80
  • MEG/MRI compatibility
  • Motivation to participate efficiently in the study
  • No severe hearing loss
  • Informed consent to participate in the study
  • Affiliation to social security
  • For brain-damaged patients : no need for medical assistance; focal temporal and/or frontal lesion; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; testing at least one-month after the event resulting in brain damage; absence of neurological and psychiatric disorders besides the lesion
  • For migraine patients: no need for medical assistance; migraine diagnosis; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; absence of neurological and psychiatric disorders besides the migraine
  • Healthy participants: absence of neurological and psychiatric disorders

Exclusion criteria

  • Age below 18 or above 80
  • MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia
  • MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.
  • Pregnant or breast-feeding women

Treatment and study plan

neuropsychological tests

Other

Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons.

Neurophysiological tests

Other

Neurophysiological tests consist in the recording of EEG and/or MEG signals while realizing the neuropsychological tests, as well as MRI scanning to characterize the patients' brain lesions and reconstruct the brain sources of surface EEG/MEG signals.

Primary outcomes

  1. Percentages of correct responses in Neuropsychological tests

    Time frame: up to 2 months

  2. reaction times in Neuropsychological tests

    Time frame: up to 2 months

Secondary outcomes

  1. Event-Related Potentials (EEG) in Neurophysiological tests

    Time frame: up to 2 months

  2. Event-Related Fields (MEG) in Neurophysiological tests

    Time frame: up to 2 months

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Consequences of a Brain Lesion or of Migraine on Auditory Processing: Attention, Memory and Emotion

Important dates

Study start
2015
Primary completion
2020
Study completion
2020
First posted
Jun 7, 2016
Registry last updated
Sep 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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