Attenuation of Pain in Men and Women

The purpose of this study is to examine opioid and endocannabinoid mechanisms of exercise-induced analgesia in men and women.

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Key information

Conditions

Pain Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Wisconsin-Madison

Madison, Wisconsin, 52706, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy men and women

Exclusion criteria

current cardiac or other chronic diseases (e.g., cancer, diabetes, hypertension, kidney disease); routine use of prescriptive medications; history of vasovagal response to phlebotomy; an allergy to naltrexone; pregnancy; current smokers; current use of recreational drugs; history of substance abuse

Treatment and study plan

Naltrexone, then placebo

Drug

50 mg of naltrexone

Placebo, then Naltrexone

Drug

sugar pill

Primary outcomes

Time for Subject to Reach Pain Threshold

Time frame: Baseline

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Registry information

Official study title

Attenuation of Pain in Men and Women: Mechanisms of Exercise-Induced Analgesia

Important dates

Study start: 2010
Primary completion: 2013
Study completion: 2013
First posted: Oct 13, 2010
Registry last updated: Feb 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed