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OpenTrials
Completed

NCT Number: NCT02041572

Attentional Bias Retraining in Veterans

The study has two goals. First to develop a computer-based intervention meant to alter cognitive biases that contribute to ongoing PTSD symptoms. Second, we sought to pilot test the intervention in a small sample of veterans for feasibility and acceptability.

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Key information

Conditions

Posttraumatic Stress Disorder Mental Disorders Stress Disorders, Post-Traumatic Stress Disorders, Traumatic Trauma and Stressor Related Disorders

Age range

18 year–89 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

National Center for PTSD

Honolulu, Hawaii, 96819, United States

About this study

Aim 1: Develop Attentional Bias Retraining protocol (Phase 1)

  • 1.1 Computerized assessment & retraining programs
  • 1.2 Procedures and measures

Aim 2: Implement in pilot sample (Phase 2)

  • 2.1: Assess feasibility and tolerability
  • 2.2: Collect pilot data to plan future studies
  • 2.3: Efficacy estimates based on changes in response time to dot probe task

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participated in ground combat operations in Vietnam
  • Scored 40 - 80 on PTSD Checklist - Military version
  • Availability and willingness to attend 2x weekly computer sessions for 6 weeks

Exclusion criteria

  • Active substance dependence
  • Significant cognitive impairment
  • Current and active suicidal or homicidal ideation

Treatment and study plan

Attentional bias retraining

Behavioral

Participants complete a computer-based intervention, which is designed to correct cognitive biases associated with PTSD by training to attend to neutral information rather than the trauma-related cue words.

Primary outcomes

  1. Post-traumatic Checklist - Military version (PCL-M)

    Time frame: Change from Baseline and Post-treatment (1 month after last training session)

    PCL-M assess the 17-cardinal symptoms of PTSD.

Secondary outcomes

  1. Attentional bias scores

    Time frame: Change from Baseline and Post-treatment (1 month after last training session)

    Attentional bias scores represent participants cognitive bias to orient towards trauma-relevant information more quickly than neutral information.

Other outcomes

  1. Daily of PTSD symptoms, specifically hyperarousal and intrusive symptoms (nightmares, reenactments, and triggered and untriggered recall)

    Time frame: Change from Baseline and Post-treatment (1 month after last training session)

    Participants filled out daily symptom log nightly

Sponsors and collaborators

Lead sponsor

VA Pacific Islands Health Care System

Fed

Registry information

Acronym: ABR

Important dates

Study start
2012
Primary completion
2012
Study completion
2015
First posted
Jan 22, 2014
Registry last updated
Nov 6, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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