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OpenTrials
Completed

NCT Number: NCT02416401

Attention Training for Learning Enhancement and Resilience Trial

Healthy aging is associated with a decline in multiple cognitive domains, as well as motor control function. The long-term consequences of cognitive and functional impairment resulting from age-related cognitive decline are well documented in the scientific and clinical literature, with significant evidence of related problems with independent functional abilities. This study aims to understand how the experimental computer program can affect cognition and attention in participants with age-related cognitive decline.

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Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Iowa, Iowa City, Iowa, United States

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About this study

Following consent, participants will engage in an assessment process to determine eligibility. Once eligibility is confirmed, participants will be scheduled for another assessment session to determine current level of cognitive function. This process consists of paper-pencil surveys and computerized tests. Following the assessment process, participants will engage in an Internet browser-delivered training sessions conducted on any internet-accessible computer. The computerized training sessions can be done up to 7 times a week (once a day) or at the participant's convenience (the recommended time commitment is 5 times a week). Following the completion of training, the participant's cognitive function will be re-assessed. Participation is voluntary and participants may withdraw from the study at any time.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants must be 65 years of age or older
  • Participants must have a diagnosis of age-related cognitive decline as confirmed by interview and performance on screening assessments
  • Participants must be fluent English speakers
  • Participants must have adequate visual, auditory, and motor capacity to use computerized intervention

Exclusion criteria

  • Participants with diagnosis of PTSD, depression or other psychologically diagnosable emotional disorder
  • Participants with a history of conditions that could affect thinking abilities, including brain injury, mental illness, cancer, or other neurological conditions (multiple sclerosis, seizure disorder), HIV/AIDS will be excluded
  • Participants enrolled in another concurrent research study will be excluded
  • Participants who have difficulty performing assessments or comprehending or following spoken instructions, in the judgment of the screening clinician, will be excluded
  • Participants with a current or significant past history of substance abuse will be excluded
  • Participants who show signs of suicidal ideations or behaviors will be excluded and referred for appropriate treatment

Treatment and study plan

Computerized plasticity-based adaptive cognitive training

Other

Commercially available computerized training

Other

Primary outcomes

  1. Attention Measures aimed to test attention

    Time frame: 6 months

    Measures aimed to test attention

  2. Executive Function

    Time frame: 6 months

    Tasks targeting inhibitory control

  3. Functional Capacity

    Time frame: 6 month

    Performance on directly observable functional measure

Secondary outcomes

  1. Quality of Sleep

    Time frame: 6 months

    assessing sleep quality

Other outcomes

  1. Quality of life

    Time frame: 6 months

    Assessments and questionnaire assessing quality of life

Sponsors and collaborators

Lead sponsor

Posit Science Corporation

Industry

Collaborators

  • Harvard Medical School (HMS and HSDM)
  • University of Iowa

Registry information

Acronym: ALERT

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Apr 15, 2015
Registry last updated
Jan 9, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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