NCT Number: NCT02416401
Attention Training for Learning Enhancement and Resilience Trial
Healthy aging is associated with a decline in multiple cognitive domains, as well as motor control function. The long-term consequences of cognitive and functional impairment resulting from age-related cognitive decline are well documented in the scientific and clinical literature, with significant evidence of related problems with independent functional abilities. This study aims to understand how the experimental computer program can affect cognition and attention in participants with age-related cognitive decline.
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Notify MeKey information
Conditions
Age range
65 year and older
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
University of Iowa, Iowa City, Iowa, United States
About this study
Following consent, participants will engage in an assessment process to determine eligibility. Once eligibility is confirmed, participants will be scheduled for another assessment session to determine current level of cognitive function. This process consists of paper-pencil surveys and computerized tests. Following the assessment process, participants will engage in an Internet browser-delivered training sessions conducted on any internet-accessible computer. The computerized training sessions can be done up to 7 times a week (once a day) or at the participant's convenience (the recommended time commitment is 5 times a week). Following the completion of training, the participant's cognitive function will be re-assessed. Participation is voluntary and participants may withdraw from the study at any time.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Participants must be 65 years of age or older
- Participants must have a diagnosis of age-related cognitive decline as confirmed by interview and performance on screening assessments
- Participants must be fluent English speakers
- Participants must have adequate visual, auditory, and motor capacity to use computerized intervention
Exclusion criteria
- Participants with diagnosis of PTSD, depression or other psychologically diagnosable emotional disorder
- Participants with a history of conditions that could affect thinking abilities, including brain injury, mental illness, cancer, or other neurological conditions (multiple sclerosis, seizure disorder), HIV/AIDS will be excluded
- Participants enrolled in another concurrent research study will be excluded
- Participants who have difficulty performing assessments or comprehending or following spoken instructions, in the judgment of the screening clinician, will be excluded
- Participants with a current or significant past history of substance abuse will be excluded
- Participants who show signs of suicidal ideations or behaviors will be excluded and referred for appropriate treatment
Treatment and study plan
Commercially available computerized training
OtherPrimary outcomes
-
Attention Measures aimed to test attention
Time frame: 6 months
Measures aimed to test attention
-
Executive Function
Time frame: 6 months
Tasks targeting inhibitory control
-
Functional Capacity
Time frame: 6 month
Performance on directly observable functional measure
Secondary outcomes
-
Quality of Sleep
Time frame: 6 months
assessing sleep quality
Other outcomes
-
Quality of life
Time frame: 6 months
Assessments and questionnaire assessing quality of life
Sponsors and collaborators
Lead sponsor
Posit Science Corporation
Industry
Collaborators
- Harvard Medical School (HMS and HSDM)
- University of Iowa
Registry information
Acronym: ALERT
Important dates
- Study start
- 2015
- Primary completion
- 2017
- Study completion
- 2017
- First posted
- Apr 15, 2015
- Registry last updated
- Jan 9, 2018
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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