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Completed

NCT Number: NCT02078258

Attention Bias Modification Treatment for Major Depressive Disorder in Adolescents

In this study, we test whether a two-week 8-session neutral attention bias modification (ABM) training and a two-week 4-session positive ABM could reduce depressive symptoms relative to placebo controls in adolescents with major depressive disorder at posttraining and follow-ups during one year.

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Key information

Conditions

Major Depressive Disorder, Single Episode, Unspecified Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders

Age range

11 year–19 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Psychology, Hunan Normal University

Changsha, Hunan, 400081, China

About this study

Depression is a common health problem in adolescents. Negative attentional bias has been theorized to play a critical role in the onset and maintenance of depression, suggesting that reduction of such biases may treat symptoms of depression. Recent studies have shown that attention bias modification(ABM) training could reduce depressive symptoms in both dysphoria and previously depressed adult patients.To test the effectiveness of ABM training on the treatment of depressive symptoms in depressed adolescents, we designed a randomized, double-blind, placebo controlled trial in adolescents with major depressive disorder(MDD).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Meet the major depression disorder's criteria

Exclusion criteria

  • bipolar disorder, schizophrenia or organic mental disorder;
  • any concurrent psychotherapy;
  • any concurrent psychotropic medication.

Treatment and study plan

ABMT

Behavioral

During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition.

Primary outcomes

  1. Changes in depressive symptom number

    Time frame: baseline, 7-week, 6-month follow-up

    Depressive symptom accounts measured by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children.

  2. Changes in depressive severity

    Time frame: baseline, 7-week, 6-month follow-up

    depressive severity measured by the construct interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children(K-SADS)

Secondary outcomes

  1. Change of Self-report symptoms

    Time frame: baseline, 7-week, 6-, 12-month follow-up

    symptoms measured by the Center for Epidemiological Studies Depression Scale (CES-D), State-Trait Anxiety Inventory-Trait(STAI-T)，Rumination Response Style（RRS)，Suicidal Ideation Questionnaire（SIQ）

  2. Diagnostic status of major depressive disorder

    Time frame: baseline, 7-week, 6-month follow-up

    Assessed by the diagnostic interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children

Sponsors and collaborators

Lead sponsor

Hunan Normal University

Other

Registry information

Official study title

Attention Bias Modification Treatment for Major Depressive Disorder in Adolescents: A Randomized Controlled Trial

Important dates

Study start
2012
Primary completion
2014
Study completion
2015
First posted
Mar 5, 2014
Registry last updated
Mar 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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