Atrovastatin for Preventing Atrial Fibrillation Following Open Cardiac Valve Repair

The purpose of the investigation is to determine whether Atrovastatin as anti-inflammatory agent can be effective in preventing from atrial fibrillation incidence in patients whom undergone open cardiac surgery for their heart valve repair.

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Key information

Conditions

Heart Valve Diseases Cardiovascular Diseases Heart Diseases

Age range

25 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Seyyed-al-Shohada Heart Center

Urmia, West Azerbaijan Province, Iran

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Greater than 25 y/o
No occurrence of intra- or post-operative cardiopulmonary arrest
Not consuming drugs affecting atrial rhythm
Having sinus rhythm before surgery
Lack of paroxysmal atrial fibrillation history
Only undergo heart valve surgery
Lack of considerable heart ischemia needed atorvastatin use
Routine cares in ward, post-operative ward, and intensive care unit were done

Exclusion criteria

Lesser than 25 y/o
History of atrial fibrillation
History of taking anti-arrhythmic drugs
History of implementing pacemakers
Severe heart failure
Renal failure
Hepatic failure
Severe pulmonary diseases
Heart block or bradyarrhythmia
Routine cares in ward, post-operative ward, and intensive care unit were not done
Performing concomitant cardiac surgery except valve repair
Having considerable heart ischemia needed atorvastatin use

Treatment and study plan

atorvastatin

Drug

Primary outcomes

Atrial Fibrillation Incidence After Open Cardiac Valve Repair

Time frame: Within 5 days after open cardiac valve repair

Sponsors and collaborators

Lead sponsor

Urmia University of Medical Sciences

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Mar 11, 2014
Registry last updated: Mar 4, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed