Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06832436

Atrial Strain in Septic Shock

Septic shock is a critical condition associated with high mortality. Transthoracic echocardiography is widely used to evaluate cardiac function and guide treatment. Left and right atrial strain (LAS and RAS) measured via speckle tracking echocardiography have shown prognostic value in cardiovascular diseases. However, differences exist between echocardiographic software, leading to challenges in result comparability. This study aims to compare LAS and RAS measurements between ECHOPAC and UWS software, evaluate AutoStrain technology, and assess reproducibility across observers. The study is non-interventional and will use retrospective echocardiographic data from patients treated for septic shock. The findings will contribute to improving measurement standardization in critically ill patients.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Septic Shock Critical Care Echocardiographic Software Infections Inflammation Left Atrial Strain Pathologic Processes Pathological Conditions, Signs and Symptoms Reproducibility Right Atrial Strain Sepsis Shock Shock, Septic Speckle Tracking Systemic Inflammatory Response Syndrome Transthoracic Echocardiography

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU Amiens

Salouël, 80480, France

Location status: Recruiting

Location contact

Christophe Beyls, MD

CONTACT

[email protected]

33 + 03 22 08 78 66

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: >18 years
  • Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)
  • TTE performed as part of medical management
  • No objection to data usage

Exclusion criteria

  • Pregnancy
  • Moderate to severe valvular regurgitation/stenosis (>grade 2)
  • Ventricular or supraventricular tachyarrhythmia (HR >140 bpm) at the time of TTE
  • Poor echogenicity preventing LAS measurement
  • Mechanical circulatory support
  • Pacemaker dependence
  • Patients under guardianship

Treatment and study plan

Primary outcomes

  1. variation of LASr between ECOPAC and UWS

    Time frame: 1 year

    Agreement of LAS Reservoir Phase (LASr) measurement in manual mode between ECHOPAC and UWS

Secondary outcomes

  1. variation of LAScd between ECHOPAC and UWS

    Time frame: 1 year

    Comparison of LAS Conduit (LAScd) measurements in manual mode between ECHOPAC and UWS

  2. variation of LASct between ECHOPAC and UWS

    Time frame: 1 year

    Comparison of LAS Conduit (LAScd) and Contraction (LASct) measurements in manual mode between ECHOPAC and UWS

  3. Comparison of LASr measurements in apical 2-chamber views

    Time frame: 1 year

    Comparison of LASr measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS

  4. Comparison of LAScd measurements in apical 2-chamber views

    Time frame: 1 year

    Comparison of LAScd measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS

  5. Comparison of LASct measurements in apical 2-chamber views

    Time frame: 1 year

    Comparison of LASct measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS

  6. Comparison of right atrial strain RASr between ECHOPAC and UWS

    Time frame: 1 year

    Comparison of right atrial strain (RASr) in manual mode between ECHOPAC and UWS

  7. Comparison of right atrial strain RAScd between ECHOPAC and UWS

    Time frame: 1 year

    Comparison of right atrial strain RAScd in manual mode between ECHOPAC and UWS

  8. Comparison of right atrial strain RASct between ECHOPAC and UWS

    Time frame: 1 year

    Comparison of right atrial strain RASct in manual mode between ECHOPAC and UWS

  9. Comparison of LAS in AutoStrain versus manual mode

    Time frame: 1 year

    Comparison of LAS measurements in AutoStrain versus manual mode on UWS

  10. Comparison of RAS in AutoStrain versus manual mode

    Time frame: 1 year

    Comparison of RAS measurements in AutoStrain versus manual mode on UWS

  11. Comparison of LAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC

    Time frame: 1 year

    Comparison of LAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC

  12. Comparison of RAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC

    Time frame: 1 year

    Comparison of RAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC

  13. Assessment of differences in LAS measurements at end-diastole between ECHOPAC and UWS

    Time frame: 1 year

    Assessment of differences in LAS phase measurements between ECHOPAC and UWS

  14. Assessment of differences in LAS measurements at pre-A between ECHOPAC and UWS

    Time frame: 1 year

    Assessment of differences in LAS measurements at pre-A between ECHOPAC and UWS

  15. Assessment of differences in RAS measurements at end-diastole between ECHOPAC and UWS

    Time frame: 1 year

    Assessment of differences in RAS measurements at end-diastole between ECHOPAC and UWS

  16. Assessment of differences in RAS measurements at pre-A between between ECHOPAC and UWS

    Time frame: 1 year

    Assessment of differences in RAS measurements at pre-A between between ECHOPAC and UWS

  17. Inter-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients

    Time frame: 1 year

    Inter-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients

  18. Intra-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients

    Time frame: 1 year

    Intra-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients

  19. Inter-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients

    Time frame: 1 year

    Inter-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients

  20. Intra-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients

    Time frame: 1 year

    Intra-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients

Study contacts

Contact information is provided by the study sponsor or research team.

Christophe Beyls, MD

CONTACT

[email protected]

33+322087866

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Collaborators

  • Henri Mondor University Hospital

Registry information

Official study title

Assessment of Left And Right Atrial Strain in Septic Shock

Acronym: ALARMS

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 18, 2025
Registry last updated
Jan 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.