Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation

Rationale

The natural history and risk factors for atrial valve disease are poorly understood and characterised. This study will examine differences between atrial mitral and atrial tricuspid disease and help us understand the natural history of these pathologies.

Study objectives

Primary objective

• Identify & characterise phenotypes in functional mitral and tricuspid valve regurgitation
• Identify risk factors for progression of disease and outcome.

Secondary objective

Compare the three groups: atrial functional MR, atrial functional TR, and mixed disease, and identify any differences/similarities.

Primary endpoint

Effective Regurgitant Orifice Area at 1 year

Secondary endpoint

• Progression of valve disease defined as worsening of mitral or tricuspid regurgitation > 1 grade at 1 year.
• Functional: New York Heart Association Class, Predicted VO2max (<84%).
• Heart Failure admission within 1 year of recruitment.
• Mortality.

Recruitment will take place from the out-patient clinics & echocardiography laboratory at St Bartholomew's Hospital

Inclusion criteria

• Informed consent
• Age of 18 years or older
• Atrial fibrillation
• Moderate or severe atrial valve disease
• Adequate 2D echocardiography views including parasternal long axis, short axis, apical two chamber, apical three chamber and four chamber.

Exclusion criteria

• Unwilling or unable to give consent
• Left ventricular impairment (ejection fraction < 50%).
• Primary/organic valve disease