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OpenTrials
Completed

NCT Number: NCT03436030

Atrial and Ventricular Wall Stress During Breathing

Healthy reclining adult volunteers, with Valsalva manoeuver, Muller manoeuver, light continuous positive airway pressure by mask, passive leg raising, and maximal hand-grip. Ultrasound heart images captured before and during.

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Key information

Conditions

Healthy

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Umeå University, and the University Hospital of Umeå

Umeå, 90185, Sweden

About this study

With focus on atrial wall strain and strain-rate, In healthy volunteer adult subjects, heart ultrasound is recorded during resting, Valsalva manoeuver, Muller manoeuver, passive leg raising, and handgrip. Echocardiographic recordings are made before and during each intervention. Participants are otherwise resting in a reclined position.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy adults

Exclusion criteria

  • known heart or lung disease

Treatment and study plan

Simple breathing manuevers during brief echocardiographic imaging

Other

Valsalva, Muller, light mask CPAP, leg raising, hand grip.

Primary outcomes

  1. Change in atrial wall stress during breathing manoeuver, compared to control measurement immediately before the breathing manoeuver

    Time frame: 30 seconds, i.e. control measurement and then measurement during breathing manoeuver observed from same breathing/measurement sequence

    Echocardiographic measure, comparing control measurement to measurement during breathing manoeuver

Sponsors and collaborators

Lead sponsor

Umeå University

Other

Collaborators

  • Region Västerbotten

Registry information

Official study title

Atrial and Ventricular Wall Stress, Effects of Breathing and Airway Pressure

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Feb 19, 2018
Registry last updated
Apr 22, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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