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OpenTrials
Completed

NCT Number: NCT01493440

Atosiban Improves Implantation and Pregnancy Rates in Patients With Repeated Implantation Failure

Atosiban, administered at embryo transfer, can improve the implantation rate and the clinical pregnancy rate in patients with repeated implantation failure undergoing IVF-ET (in-vitro fertilization and embryo transfer).

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Key information

Conditions

Repeated Implantation Failure

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

IVFAS, An Sinh Hospital

Ho Chi Minh City, Ho Chi Minh, 8, Vietnam

About this study

Atosiban is a mixed oxytocin and vasopressin V1A receptor antagonist.Combined antagonism at oxytocin and vasopressin V1A receptors reduces uterine contractions with a corresponding decrease in intrauterine production of prostaglandin F2alpha and improved uterine blood supply. These effects are of potential benefit for implantation support during IVF-ET cycles.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • had repeated implantation failure
  • have at least 1 good quality embryo for transfer

Exclusion criteria

  • uterine abnormalities that could compromise the implantation process (e.g. fibroids, endometrial polyp, bicornuate uterus, adhesion of uterine cavity)

Treatment and study plan

Atosiban

Drug

Atosiban was administered as a 6.75mg IV bolus dose 30 minutes prior to embryo transfer followed by a 1-hour IV infusion at dose of 18 mg/h then a 2-hour IV infusion at 6 mg/h.

Other names: Tractocile

Primary outcomes

  1. Clinical pregnancy

    Time frame: 5 weeks after intervention

Sponsors and collaborators

Lead sponsor

An Sinh Hospital

Other

Collaborators

  • Vietnam National University

Registry information

Important dates

Study start
2011
Primary completion
2011
Study completion
2011
First posted
Dec 16, 2011
Registry last updated
Dec 20, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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