ATM Variants in Radiotherapy Patients

The purpose of this study is to compare the baseline incidence of variant alleles in the ATM and/or other DNA repair genes present in the Native American population versus the non-Native American population. It is thought that a higher baseline incidence of the variant alleles in the ATM gene may correlate to higher rates and higher grades of radiation toxicities noted in the Native American population.

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Key information

Conditions

Radiotherapy

Age range

18 year and older

Sex eligibility

Male

Study type

Observational

Primary location

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Indication for radiotherapy.
Ability or desire to donate a blood sample and be followed closely for radiation toxicities

Treatment and study plan

Primary outcomes

to determine baseline incidence of variant alleles in ATM

Time frame: one blood draw

to determine the baseline incidence of variant alleles in ATM resent in the population of Native americans with cancer who are undergoing radiation therapy to a similar group of non-native americans who have undergone or are undergoing raditohterapy

Secondary outcomes

to compare the baseline incidence of variant alleles in ATM

Time frame: one blood draw

to compare the baseline incidence of variant alleles in ATM resent in the population of Native americans with cancer who are undergoing radiation therapy to a similar group of non-native americans who have undergone or are undergoing raditohterapy

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Registry information

Official study title

ATM Variants in Radiotherapy

Important dates

Study start: 2007
Primary completion: 2013
Study completion: 2013
First posted: Sep 21, 2005
Registry last updated: Nov 19, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed