Atherosclerotic Plaque Characterization

The purpose of this study is to utilize high-resolution CMR carotid imaging for the characterization of carotid wall volumes and plaque content in patients with clinical significant carotid atherosclerosis. Patients who are scheduled to undergo an imaging procedure will be recruited from the cath lab. Upon enrollment, blood samples conventional and genetic profiling will be collected. For patients undergoing a carotid endarterectomy, tissue from the carotid vessel will be collected during their procedure. Comparison of the MR images with tissue and/or blood samples will be made. Length of time in the study will be approximately 1 day. There will be no study-related patient follow-up.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Piedmont Hospital

Atlanta, Georgia, 30309, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age range >17 years of age
Surgical carotid artery disease
Provide written informed consent and Authorization for Use/Disclosure of PHI

Exclusion criteria

History of carotid trauma
History of middle or large vessel vasculitis
Refusal to provide written informed consent and Authorization for
Use/Disclosure of PHI

Treatment and study plan

Primary outcomes

Characterization of plaque that is found in the carotid walls of patients who have atherosclerosis

Time frame: 2 years post study initiation

Secondary outcomes

To evaluate the effectiveness of MR imaging in identifying these plaque characteristics

Time frame: 2 Years Post Study Initiation

Sponsors and collaborators

Lead sponsor

Piedmont Healthcare

Other

Registry information

Official study title

Atherosclerotic Plaque Characterization Using Multispectral, Multicontrast High Resolution Cardiovascular Magnetic Resonance Imaging

Acronym: APC

Important dates

Study start: 2006
Primary completion: 2011
Study completion: 2013
First posted: Mar 13, 2009
Registry last updated: Apr 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed