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OpenTrials
Completed

NCT Number: NCT06069414

Atelectasis After Inhalation or Intravenous Induction in Pediatric Anesthesia

Children have a highly compliant chest wall and atelectasis formation occurs often during pediatric anesthesia. Inhalation induction is commonly performed in pediatric anesthesia but it is still unclear if this can have an effect on the development of atelectasis. Aim of this study is to investigate the impact of inhalation versus intravenous induction on atelectasis formation during anesthesia induction in children. Atelectasis will be evaluated with lung ultrasound before induction and right after induction.

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Key information

Age range

0 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Vittore Buzzi Children's Hospital

Milan, 20154, Italy

About this study

Respiratory complications, among which atelectasis, are a common cause of adverse events in pediatric anesthesia. Lung ultrasound (LUS) examination is a point of care, non-invasive, radiation-free tool with high sensitivity and specificity for the identification of anesthesia-induced atelectasis in children.

Inhalation induction is commonly performed in pediatric anesthesia to avoid pain at venipuncture or to facilitate vein cannulation. This technique has been associated with a higher rate of respiratory adverse events but no study has investigated the role of inhalation or intravenous induction on lung atelectasis development in pediatric anesthesia.

The investigators will perform this study aiming to describe the impact of inhalation versus intravenous induction technique on atelectasis formation during anesthesia induction in children of different ages.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • scheduled for elective surgery under general anesthesia
  • parental consent

Exclusion criteria

  • American Society of Anesthesiologists (ASA) physical status III-VI
  • neuromuscular disease
  • chronic lung disease
  • cardiopathy
  • thoracic cage malformations
  • chronic home ventilation (either invasive or non-invasive)
  • positive history of foreign body inhalation
  • required immediate life-saving procedures
  • lack of parental consent

Treatment and study plan

Type of anesthesia induction

Other

Patients will receive inhalatory or intravenous anesthesia at their choice; both groups will be evaluated with lung ultrasound after induction to detect ultrasonografic signs of atelectasis

Primary outcomes

  1. Global LUS score

    Time frame: Upon completion of induction and subsequent controls at end of surgery and 1 postoperative day

    Sum of the LUS scores given to all the lung areas. Score points vary from 0 to 3, where 0 means normality of the lung and 3 refers to complete loss of aeration-tissue-like pattern or consolidation.

  2. Signs of atelectasis

    Time frame: Upon completion of induction and and subsequent controls at end of surgery and 1 postoperative day

    Number of lung areas presenting a sub pleural consolidation

Sponsors and collaborators

Lead sponsor

Vittore Buzzi Children's Hospital

Other

Registry information

Official study title

Atelectasis Evaluated With Lung Ultrasound After Inhalation or Intravenous Induction in Pediatric Anesthesia: a Prospective, Observational, Propensity Scored Matched Study

Acronym: AtelectLUS

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Oct 5, 2023
Registry last updated
Apr 17, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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