Associations of Fecal Bile Acid Profile and Intestinal Flora With Chronic Radiation Enteritis

Inclusion criteria

• . non-surgical cervical cancer patients aged 18 to 75 years who received radiotherapy;
• . Patients who can fully understand the content of informed consent for this trial and voluntarily sign the written informed consent;
• . able to receive follow-up examinations, follow-up examinations, and specimen retention on time;
• . The case group met the diagnostic criteria for chronic radiation enteritis in the "Expert Consensus on the Diagnosis and Treatment of Radiation Proctitis in China (2018 edition)"; Control group 1: Non-surgical cervical cancer patients without chronic radiation enteritis after radiotherapy; Control group 2: Patients with cervical cancer who did not receive any treatment.

Exclusion criteria

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• . Presence of diseases affecting bile acid metabolism, such as hepatitis and cirrhosis of the liver from various causes, gallstones, etc;
• . Patients who have previously undergone cholecystectomy or partial resection of the intestine;
• . Taking drugs affecting bile acid metabolism due to other diseases, such as cholestyramine, anti-inflammatory and Xiaoyan lidan tablets, Danshu capsules, ursodeoxycholic acid, obeticholic acid, and proprietary Chinese medicines such as schisandrin B, Tanshinone IIA, and Yinjiazhuang;
• . Recent use of drugs that affect gastrointestinal motility;
• . Patients with moderate or severe renal impairment (blood creatinine > 2 mg/dL or 177 mmol/L), or abnormal liver function (ALT > 2 times the upper limit of normal value); moderate or severe chronic obstructive pulmonary disease; patients with severe hypertension, patients with cerebrovascular accidents; patients with congestive heart failure, unstable angina pectoris;
• . Patients with mental or legal disabilities;
• . Suspected or confirmed history of alcohol/substance abuse or other pathology that, in the judgment of the investigator, reduces the likelihood of enrollment or complicates enrollment;
• . Refuse to sign informed consent;