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OpenTrials
Completed

NCT Number: NCT02096991

Associations of Exposure to Bisphenol A With Blood Pressure and Epigenetic Change

* Bisphenol A(BPA) is an endocrine disrupting chemical, which mimics the action of estrogen. * Previous studies reported that BPA exposure is associated with increased risk of cardiovascular diseases. * Exposure to BPA occur mainly through oral route, and epoxy coating of canned food is one of the well established source. * The investigators hypothesis is that increased BPA exposure from canned beverage would disrupt normal physiology in a short term. * In the present trial the investigators are to investigate whether increased BPA exposure by consuming canned beverage actually affect cardiovascular indices and epigenetic feature. * For this aim, the investigators will conduct a cross-over trial.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

60 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Preventive Medicine, College of Medicine, Seoul National University

Seoul, 110-799, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Reside in Seoul
  • Who provided Informed consent

Exclusion criteria

  • Who has cancer
  • Who has disease or disorder of liver, nervous system, endocrine system, cardiovascular system
  • Who does not provieded informed consent

Treatment and study plan

Can 1

Other

drink the beverage in a can and a glass bottle

Can 2

Other

Consume two canned beverage

Glass

Other

consume two glass bottled beverage

Primary outcomes

  1. Blood Pressure

    Time frame: 2 hours after consuming beverage

Secondary outcomes

  1. Percent DNA methylation

    Time frame: 2 hours after consuming the beverage

  2. Heart Rate Variablility

    Time frame: 2 hours after consuming the beverage

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Mar 26, 2014
Registry last updated
Mar 26, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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