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NCT Number: NCT07132723

Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty

The aim of the study is to investigate the impact of time to closed reduction on both patient related and organizational factors. These include, length of stay, hospitalization, admission to intensive care unit, rehospitalizations, delirium, all-cause mortality, infection requiring hospital contact, and cardiovascular complications. It is also intended to investigate whether different anaesthetic strategies and airway management are associated with different complication rates.

It is hypothesized that longer waiting time until reduction increase the postoperative length of stay, readmissions, and risk of complications.

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Key information

Conditions

Closed Reduction Arthroplasty, Replacement, Hip Length of Stay

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesiology, North Zeeland Hospital

Hillerød, 3400, Denmark

Location contact

Lars Lundstrøm

CONTACT

[email protected]

+4548296512

Rikke HF Bjulf, Research Fellow

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients will be considered eligible for inclusion if they meet all of the following criteria:

  • Aged 18 years or older
  • Presented to the emergency department with a dislocated total hip arthroplasty.
  • Undergo closed reduction of the dislocated total hip arthroplasty in the operating theatre, with the involvement of the Department of Anesthesiology.

Exclusion criteria

  • Were primarily booked for open surgical reduction.
  • Did not have a complete case log (i.e. time of admission; referral to the operation theatre; anesthesia induction; discharge, etc.) and we were unable to recreate the log using simple code rules.

Treatment and study plan

Time in minutes from admission to closed reduction

Other

Time in minutes from admission to closed reduction measured as: From arriving time in the emergency department until the start of surgery in the operating theater.

Other names: - Time of day, - Weekday vs. weekend, - Airway management, - Anesthesia method(s), - Neuromuscular blocking agent (Yes/No)

Primary outcomes

  1. Post procedure length of stay

    Time frame: 30 days after the closed reduction

    Post procedure length of stay from closed reduction until discharge from the hospital (hours)

Secondary outcomes

  1. All-cause mortality

    Time frame: 90 days after closed reduction

    90 days all-cause mortality (Y/N)

  2. Admissions to Intensive care unit

    Time frame: 30 days after the closed reduction

    Admissions to the intensive care unit within 30 days after the closed reduction.

  3. Readmission

    Time frame: 30 days after discharge

    Readmission within 30 days after discharge

  4. Delirium during admission

    Time frame: From admission to discharge up to 30 days after closed reduction

    Defined as diagnose of delirium (F05.x, obtained from the diagnosis codes from the given admission) or the non-planned administration of haloperidol, olanzapine, risperidone, or quetiapine (as a surrogate for new onset delirium)

  5. Acute kidney failure

    Time frame: Post procedure until 30 days after discharge

    Defined as serum creatinine increase of more than 25 μmol/L within a period of less than 48 hours. (As a surrogate for acute kidney failure)

  6. Infection requiring hospital contact

    Time frame: Post procedure until 30 days after discharge

    Defined as diagnosed infection (postoperative infection (T81.4), pneumonia (J13.x-J18.x), Cystitis (N30.x, N39.0), sepsis (R65.x A40.x, A41.x), C. difficile (A04.7) obtained from the diagnose codes from the given admission) or administration of antibiotic treatment (as a surrogate for in-hospital infection

  7. Cardiovascular complications

    Time frame: From admission to 30 days after discharge.

    Defined as diagnosed arrythmia (I47.x, I48.x, I49.x), myocardial infarction (I21.x, I22.x), cerebral ischemia (I61.x, I63.x, I64.x), hemorrhage(T81), pulmonary embolism(I26.x) or deep venous thrombosis(I80.2) (obtained from the diagnosis codes from the given admission)

Study contacts

Contact information is provided by the study sponsor or research team.

Lars H Lundstrøm, MD, PhD

CONTACT

[email protected]

+4548296512

Rikke HF Bjulf, Research fellow

CONTACT

rikke.helene.frø[email protected]

Sponsors and collaborators

Lead sponsor

Nordsjaellands Hospital

Other

Registry information

Official study title

Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty - A Protocol for an Observational Cohort Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 20, 2025
Registry last updated
Aug 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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